Genome instability syndromes caused by impaired DNA repair and aberrant DNA damage responses

Maintenance of null integrity is essential for all organisms because null information regulates cell proliferation, growth arrest, and vital metabolic processes in cells, tissues, organs, and organisms. Because genomes are constantly exposed to intrinsic and extrinsic genotoxic stress, cellular DNA repair machinery and proper DNA damage responses (DDR) have evolved to quickly eliminate genotoxic DNA lesions, thus maintaining the null integrity...