Cell Biology and Toxicology
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6.28
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1389
Papers 1498
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#1Dinesh Babu Somasundaram (University of Oklahoma Health Sciences Center)H-Index: 7
#2Sheeja Aravindan (OU: University of Oklahoma)H-Index: 14
Last. Natarajan AravindanH-Index: 22
view all 5 authors...
Neuroblastoma (NB) progression is branded with hematogenous metastasis and frequent relapses. Despite intensive multimodal clinical therapy, outcomes for patients with progressive disease remain poor, with negligible long-term survival. Therefore, understanding the acquired molecular rearrangements in NB cells with therapy pressure and developing improved therapeutic strategies is a critical need to improve the outcomes for high-risk NB patients. We investigated the rearrangement of MMP9 in NB w...
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#1Boyuan Zhao (Chongqing University)H-Index: 1
#2Yonggang Lv (Chongqing University)H-Index: 22
Except for biochemical effects, suspension state (Sus) is proved to induce epithelial-mesenchymal transition (EMT) of circulating tumor cells (CTCs) mechanically. However, the difference between the effects of the mechanical microenvironment in capillaries (simplified as shear stress (SS) and Sus) and single Sus on EMT is unclear, nor the underlying mechanism. Here, breast tumor cells (BTCs) were loaded with Sus and SS to mimic the situation of CTCs stimulated by these two kinds of mechanics. It...
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#1U Sangeetha Shenoy (Manipal University)
#2Divya Adiga (Manipal University)H-Index: 3
Last. Raghu Radhakrishnan (Manipal University)H-Index: 14
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Homeobox (HOX) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between altered gene expression of individual HOX genes and tumorigenesis. This review focuses on how deregulation in the HOX-associated signaling pathways contributes to the metastatic progression in cancer. ...
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#1Sung-Won Kim (SKKU: Sungkyunkwan University)H-Index: 4
#2Yu-Jin Kim (SKKU: Sungkyunkwan University)H-Index: 4
Last. Suk Ho Bhang (SKKU: Sungkyunkwan University)H-Index: 19
view all 8 authors...
Low-level light therapy (LLLT) is a safe and noninvasive technique that has drawn attention as a new therapeutic method to treat various diseases. However, little is known so far about the effect of blue light for LLLT due to the generation of reactive oxygen species (ROS) that can cause cell damage. We introduced a blue organic light-emitting diode (bOLED) as a safe and effective light source that could generate a low amount of heat and luminance compared to conventional light sources (e.g., li...
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#1Myriam Mireault (UQAM: Université du Québec à Montréal)H-Index: 1
#2Yong Xiao (UQAM: Université du Québec à Montréal)H-Index: 2
Last. Catherine Jumarie (UQAM: Université du Québec à Montréal)H-Index: 18
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Cadmium is a toxic metal that enters the food chain. Following oral ingestion, the intestinal epithelium has the capacity to accumulate high levels of this metal. We have previously shown that Cd induces ERK1/2 activation in differentiated but not proliferative human enterocytic-like Caco-2 cells. As autophagy is a dynamic process that plays a critical role in intestinal mucosa, we aimed the present study 1) to investigate the role of p-ERK1/2 in constitutive autophagy in proliferative Caco-2 ce...
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#1Qirong Lu (HAU: Huazhong Agricultural University)H-Index: 5
#2Pu Guo (HAU: Huazhong Agricultural University)H-Index: 2
Last. Arturo Anadón (Complutense University of Madrid)H-Index: 35
view all 11 authors...
Alimentary toxic aleukia (ATA) is correlated with consuming grains contaminated by Fusarium species, particularly T-2 toxin, which causes serious hurt to human and animal health, chiefly in disorders of the haematopoietic system. However, the mechanism of haematopoietic dysfunction induced by T-2 toxin and the possible target pathway for the treatment of T-2 toxin-induced haematopoietic disorder of ATA remains unclear. In this study, genomes and proteomics were used for the first time to investi...
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#1Rusong Yang (Nanjing Medical University)H-Index: 2
#2Zhengcheng Liu (Nanjing Medical University)H-Index: 2
Last. Ye Shi (Nanjing Medical University)H-Index: 1
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Purpose null LINC01089 is a newly identified lncRNA and rarely reported in human cancers. Our study aimed to investigate its role in lung cancer. null Methods null YY1, LINC01089, and miR-301b-3p levels in lung cancer tissues and cells were assessed using qRT-PCR. Bioinformatics analysis and luciferase reporter, ChIP, and RIP assays were carried out for determining the relationships among YY1, LINC01089, miR-301b-3p, and HPGD. Gain- and loss-of-function assays were carried out to confirm the imp...
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#1Junfeng Ye (JLU: Jilin University)
#2Yu Fu (JLU: Jilin University)
Last. Jinhai Yu (JLU: Jilin University)
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Some studies have reported the effect of long non-coding RNA forkhead box P4 antisense RNA 1 (lncRNA FOXP4-AS1) on hepatocellular carcinoma (HCC). Here, we aimed to discuss the effects of FOXP4-AS1/enhancer of zeste homolog 2 (EZH2)/trimethylation of lysine 27 on histone H3 (H3K27me3)/zinc finger CCCH-type containing 12D (ZC3H12D) axis on HCC. The expression of FOXP4-AS1, EZH2, and ZC3H12D, and abundance of H3K27me3 in HCC tissues and cells were tested. The relationship between FOXP4-AS1 express...
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#1Xiaohan Gong (WHU: Wuhan University)
#2Shiyun Dai (WHU: Wuhan University)H-Index: 1
Last. Dan Xu (WHU: Wuhan University)H-Index: 17
view all 10 authors...
Prenatal dexamethasone exposure (PDE) induces long-term reproductive toxicity in female offspring. We sought to explore the transgenerational inheritance effects of PDE on diminished ovarian reserve (DOR) in female offspring. Dexamethasone was subcutaneously administered into pregnant Wistar rats from gestational day 9 (GD9) to GD20 to obtain fetal and adult offspring of the F1 generation. F1 adult females were mated with normal males to produce the F2 generation, and the F3 generation. The find...
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#1Jing Zhao (Nanjing Medical University)H-Index: 1
#2Haibo Xia (SEU: Southeast University)
Last. Qizhan Liu (Nanjing Medical University)H-Index: 31
view all 9 authors...
Cigarette smoke (CS), a main source of indoor air pollution, is a primary risk factor for emphysema, and aberrant cellular autophagy is related to the pathogenesis of emphysema. Circular RNAs (circRNAs) affect the expression of mRNAs via acting as microRNA (miRNA) sponges, but their role in emphysema progression is not established. In the present investigation, CS, acting on alveolar epithelial cells, caused higher levels of miR-21, p-ERK, and cleaved-caspase 3 and led to lower levels of circRNA...
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