Ability of FDG PET and CT radiomics features to differentiate between primary and metastatic lung lesions

Published on Apr 6, 2018in European Journal of Nuclear Medicine and Molecular Imaging7.081
· DOI :10.1007/S00259-018-3987-2
Margarita Kirienko20
Estimated H-index: 20
(Humanitas University),
Luca Cozzi22
Estimated H-index: 22
(Humanitas University)
+ 5 AuthorsMartina Sollini22
Estimated H-index: 22
(Humanitas University)
Purpose To evaluate the ability of CT and PET radiomics features to classify lung lesions as primary or metastatic, and secondly to differentiate histological subtypes of primary lung cancers.
Figures & Tables
📖 Papers frequently viewed together
254 Citations
75 Citations
2,200 Citations
#1Margarita Kirienko (Humanitas University)H-Index: 20
#2Luca CozziH-Index: 64
Last. Martina Sollini (Humanitas University)H-Index: 22
view all 9 authors...
Purpose Radiomic features derived from the texture analysis of different imaging modalities e show promise in lesion characterisation, response prediction, and prognostication in lung cancer patients. The present study aimed to identify an images-based radiomic signature capable of predicting disease-free survival (DFS) in non-small cell lung cancer (NSCLC) patients undergoing surgery.
75 CitationsSource
#1Philippe Lambin (Maastricht University Medical Centre)H-Index: 113
#2Ralph T.H. Leijenaar (Maastricht University Medical Centre)H-Index: 29
Last. Sean Walsh (UM: Maastricht University)H-Index: 11
view all 20 authors...
Radiomics is the high-throughput mining of quantitative image features from standard-of-care medical imaging to enable data to be extracted and applied within clinical-decision support systems. The process of radiomics is described and its pitfalls, challenges, opportunities, and capacity to improve clinical decision making. The radiomics field requires standardized evaluation of scientific findings and their clinical relevance. This review provides guidance for investigations to meet this urgen...
1,107 CitationsSource
#1M. Craigie (Princess Alexandra Hospital)H-Index: 1
#2J. Squires (Princess Alexandra Hospital)H-Index: 1
Last. Kenneth A. Miles (UCL: University College London)H-Index: 56
view all 3 authors...
Aim To undertake a preliminary assessment of the potential for computed tomography (CT) measurement of tumour heterogeneity to stratify risk of nodal metastasis in patients with non-small cell lung cancer (NSCLC). Materials and methods Tumour heterogeneity in CT images from combined positron-emission tomography (PET)/CT examinations in 150 consecutive patients with NSCLC was assessed using CT texture analysis (CTTA). The short axis diameter of the largest mediastinal node was also measured. Fort...
8 CitationsSource
#1Francesco Petrella (University of Milan)H-Index: 23
#2Cristina Diotti (IEO: European Institute of Oncology)H-Index: 4
Last. Lorenzo Spaggiari (IEO: European Institute of Oncology)H-Index: 59
view all 4 authors...
Metastasectomy is the most frequent surgical resection undertaken by thoracic surgeons, being the lung the second common site of metastases. The present oncological criteria for pulmonary metastasectomy are: (I) the primary cancer need to be controlled or controllable; (II) no extrathoracic metastasis—that is not controlled or controllable—exists; (III) all of the tumor must be resectable, with adequate pulmonary reserve; (IV) there are no alternative medical treatment options with lower morbidi...
26 CitationsSource
#1Bojiang Chen (Sichuan University)H-Index: 6
#2Rui Zhang (Sichuan University)H-Index: 5
Last. Weimin Li (Sichuan University)H-Index: 24
view all 5 authors...
Since the discovery of X-rays at the end of the 19th century, medical imageology has progressed for 100 years, and medical imaging has become an important auxiliary tool for clinical diagnosis. With the launch of the human genome project (HGP) and the development of various high-throughput detection techniques, disease exploration in the post-genome era has extended beyond investigations of structural changes to in-depth analyses of molecular abnormalities in tissues, organs and cells, on the ba...
36 CitationsSource
#1Song Chen (PRC: China Medical University (PRC))H-Index: 8
#2Stephanie Harmon (UW: University of Wisconsin-Madison)H-Index: 15
Last. Robert Jeraj (UW: University of Wisconsin-Madison)H-Index: 46
view all 7 authors...
Lung cancer, the most commonly diagnosed cancer worldwide, usually presents as solid pulmonary nodules (SPNs) on early diagnostic images. Classification of malignant disease at this early timepoint is critical for improving the success of surgical resection and increasing 5-year survival rates. 18F-fluorodeoxyglucose (18F-FDG) PET/CT has demonstrated value for SPNs diagnosis with high sensitivity to detect malignant SPNs, but lower specificity in diagnosing malignant SPNs in populations with end...
28 CitationsSource
#1Margarita Kirienko (Humanitas University)H-Index: 20
#2Francesca Gallivanone (National Research Council)H-Index: 16
Last. Arturo Chiti (Humanitas University)H-Index: 54
view all 10 authors...
Objective of this work was to evaluate the role of 18F-fluorodeoxyglucose (FDG) positron-emission tomography features as theranostic imaging biomarkers in non-small cell lung cancer. In a retrospective protocol, 31 stage I-III NSCLC patients were enrolled. Patients underwent FDG PET/CT for staging purposes before surgery and were followed for two years after surgery. PET images were quantitatively analyzed. For the primary lesion, metabolic tumour volume, maximum standardized uptake value (SUV),...
7 CitationsSource
#1Paul Flechsig (University Hospital Heidelberg)H-Index: 14
#2Philipp Frank (University Hospital Heidelberg)H-Index: 1
Last. Frederik L. Giesel (University Hospital Heidelberg)H-Index: 60
view all 12 authors...
Purpose Mediastinal nodal (N)-staging done by integrated 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) positron emission tomography/x-ray computed tomography (PET/CT) in lung cancer patients is not always accurate. In order to reduce the need for invasive staging procedures, additional surrogate parameters for the detection of malignant lymph node infiltration would be helpful. The purpose of this study was to evaluate if radiomic semi-automated density profiling in mediastinal lymph nodes can impr...
14 CitationsSource
#1Martina Sollini (Humanitas University)H-Index: 22
#2Luca Cozzi (Humanitas University)H-Index: 22
Last. Margarita Kirienko (Humanitas University)H-Index: 20
view all 5 authors...
Imaging with positron emission tomography (PET)/computed tomography (CT) is crucial in the management of cancer because of its value in tumor staging, response assessment, restaging, prognosis and treatment responsiveness prediction. In the last years, interest has grown in texture analysis which provides an “in-vivo” lesion characterization, and predictive information in several malignances including NSCLC; however several drawbacks and limitations affect these studies, especially because of la...
82 CitationsSource
#1Heber MacMahon (U of C: University of Chicago)H-Index: 78
#2David P. Naidich (NYU: New York University)H-Index: 81
Last. Alexander A. Bankier (Harvard University)H-Index: 58
view all 15 authors...
The minimum threshold size for routine follow-up has been increased, and recommended follow-up intervals are now given as a range rather than as a precise time period to give radiologists, clinicians, and patients greater discretion to accommodate individual risk factors and preferences.
749 CitationsSource
Cited By56
#1Yumin Hu (ZJU: Zhejiang University)H-Index: 1
#2Qiaoyou Weng (ZJU: Zhejiang University)H-Index: 6
Last. Jiansong Ji (ZJU: Zhejiang University)H-Index: 6
view all 10 authors...
PURPOSE To develop and validate a radiomic nomogram based on arterial phase of CT to discriminate the primary ovarian cancers (POCs) and secondary ovarian cancers (SOCs). METHODS A total of 110 ovarian cancer patients in our hospital were reviewed from January 2010 to December 2018. Radiomic features based on the arterial phase of CT were extracted by Artificial Intelligence Kit software (A.K. software). The least absolute shrinkage and selection operation regression (LASSO) was employed to sele...
#1Katsuya Mitamura (Kagawa University)H-Index: 3
#2Takashi Norikane (Kagawa University)H-Index: 7
Last. Yoshihiro Nishiyama (Kagawa University)H-Index: 40
view all 10 authors...
We assessed the role of 18F-FDG PET/CT texture indices for the differentiation of squamous cell carcinoma (SCC) and non-Hodgkin's lymphoma (NHL) in the oropharynx. 18F-FDG PET/CT data for 27 patients with SCC and 25 patients with NHL in the oropharynx were investigated. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and six texture indices (homogeneity, entropy, short-run emphasis, long-run emphasis, low gray-level zone emphasis [LGZE...
#1Lukas LengaH-Index: 12
#2Simon BernatzH-Index: 7
Last. Doris LeithnerH-Index: 14
view all 8 authors...
Dual-energy CT (DECT) iodine maps enable quantification of iodine concentrations as a marker for tissue vascularization. We investigated whether iodine map radiomic features derived from staging DECT enable prediction of breast cancer metastatic status, and whether textural differences exist between primary breast cancers and metastases. Seventy-seven treatment-naive patients with biopsy-proven breast cancers were included retrospectively (41 non-metastatic, 36 metastatic). Radiomic features inc...
#1Margarita Kirienko (Humanitas University)H-Index: 20
#2Martina Sollini (Humanitas University)H-Index: 22
Last. Arturo Chiti (Humanitas University)H-Index: 54
view all 12 authors...
OBJECTIVE The objectives of our study were to assess the association of radiomic and genomic data with histology and patient outcome in non-small cell lung cancer (NSCLC). METHODS In this retrospective single-centre observational study, we selected 151 surgically treated patients with adenocarcinoma or squamous cell carcinoma who performed baseline [18F] FDG PET/CT. A subgroup of patients with cancer tissue samples at the Institutional Biobank (n = 74/151) was included in the genomic analysis. F...
1 CitationsSource
#1Vincenzo AmbrogiH-Index: 30
#2Alessandro Tamburrini (University of Southampton)H-Index: 2
view all 3 authors...
Repeat surgical resection (redo) for pulmonary metastases is a questionable, albeit intriguing topic. We performed an extensive review of the literature, to specifically analyze results of redo pulmonary metastasectomies. We reviewed a total of 3,523 papers. Among these, 2,019 were excluded for redundancy and 1,105 because they were not completely retrievable. Out of 399 eligible papers, 183 had missing information or missing abstract, while 96 lacked data on survival. A total of 120 papers date...
#1Lalith Kumar Shiyam Sundar (Medical University of Vienna)H-Index: 5
#2Otto Muzik (WSU: Wayne State University)H-Index: 73
Last. Thomas Beyer (Medical University of Vienna)H-Index: 58
view all 5 authors...
State-of-the-art patient management frequently mandates the investigation of both anatomy and physiology of the patients. Hybrid imaging modalities such as the PET/MRI, PET/CT and SPECT/CT have the ability to provide both structural and functional information of the investigated tissues in a single examination. With the introduction of such advanced hardware fusion, new problems arise such as the exceedingly large amount of multi-modality data that requires novel approaches of how to extract a m...
#1Reyhaneh Manafi-Farid (Tehran University of Medical Sciences)H-Index: 4
#2Najme Karamzade-Ziarati (Tehran University of Medical Sciences)H-Index: 1
Last. Mohsen Beheshti (RWTH Aachen University)H-Index: 4
view all 5 authors...
Abstract Lung cancer is the most common cancer, worldwide, and a major health issue with a remarkable mortality rate. 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (2-[18F]FDG PET/CT) plays an indispensable role in the management of lung cancer patients. Long-established quantitative parameters such as size, density, and metabolic activity have been and are being employed in the current practice to enhance interpretation and improve diagnostic and prognostic va...
2 CitationsSource
Background: The paper presents a pre-processing method which, based on positron-emission tomography (PET) images of 18F-fluorodeoxyglucose ([18F] FDG) hypermetabolic pulmonary nodules, makes it possible to obtain additional visual characteristics and use them to enhance the specificity of imaging. Material and Methods: A retrospective analysis of 69 FDG-PET/CT scans of solitary hypermetabolic pulmonary nodules (40 cases of lung cancer and 29 benign tumours), where in each case, the standardised ...
#1Guangyao Wu (Maastricht University Medical Centre)
#1Guangyao Wu (HUST: Huazhong University of Science and Technology)
Last. Philippe Lambin (Maastricht University Medical Centre)H-Index: 113
view all 7 authors...
INTRODUCTION Lung cancer ranks second in new cancer cases and first in cancer-related deaths worldwide. Precision medicine is working on altering treatment approaches and improving outcomes in this patient population. Radiological images are a powerful non-invasive tool in the screening and diagnosis of early-stage lung cancer, treatment strategy support, prognosis assessment, and follow-up for advanced-stage lung cancer. Recently, radiological features have evolved from solely semantic to inclu...