Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

Highlights•An overview of PanCancer Atlas analyses on oncogenic molecular processes•Germline genome affects somatic genomic landscape in a pathway-dependent fashion•Genome mutations impact expression, signaling, and multi-omic profiles•Mutation burdens and drivers influence immune-cell composition in microenvironmentSummaryThe Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human...