Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1
Abstract
Glucagon-like peptide-1 (GLP-1) released from gut enteroendocrine cells controls meal-related glycemic excursions through augmentation of insulin and inhibition of glucagon secretion. GLP-1 also inhibits gastric emptying and food intake, actions maximizing nutrient absorption while limiting weight gain. Here I review the circuits engaged by endogenous versus pharmacological GLP-1 action, highlighting key GLP-1 receptor (GLP-1R)-positive cell...
Paper Details
Title
Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1
Published Date
Apr 1, 2018
Journal
Volume
27
Issue
4
Pages
740 - 756
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