Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer
Abstract
ARID1A, a subunit of the SWI/SNF complex, is among the most frequently mutated genes across cancer types. ARID1A is mutated in more than 50% of ovarian clear cell carcinomas (OCCCs), diseases that have no effective therapy. Here, we show that ARID1A mutation confers sensitivity to pan-HDAC inhibitors such as SAHA in ovarian cancers. This correlated with enhanced growth suppression induced by the inhibition of HDAC2 activity in ARID1A-mutated...
Paper Details
Title
Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer
Published Date
Mar 1, 2018
Journal
Volume
22
Issue
13
Pages
3393 - 3400
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