Cystic Fibrosis Sputum Rheology Correlates With Both Acute and Longitudinal Changes in Lung Function

Cystic fibrosis (CF) airway secretions are abnormal, contributing to decreased clearance and a cycle of infection and inflammation. CF sputum properties may predict disease progression. We hypothesized that sputum viscoelasticity and clearance abnormalities would inversely correlate with pulmonary function during exacerbation and that sputum properties would return to baseline after therapy.We collected sputa longitudinally from 13 subjects with...