Clinical evidence of the vascular protective effects of grapefruit flavanones in post-menopausal women and potential molecular mechanisms involved

Epidemiological studies reported that a high flavanone intake is associated with a reduced risk of cardiovascular diseases (Mink et al, 2007; Cassidy et al, 2012), however clinical evidence is still lacking. We carried out a cross-over RCT on 52 healthy post-menopausal women who have to consumed daily and for 6-month, 340ml of grapefruit juice (providing 212mg naringenin-glycosides) or of an iso-energetic control beverage mimicking the...