Christine Morand
University of Auvergne
ExcretionInternal medicineEndocrinologyBioavailabilityChemistryHesperidinInflammationAntioxidantFlavonoidQuercetinIntestinal absorptionPlant foodsFood scienceChromatographyBiochemistryMetabolismPolyphenolMedicineBiologyCell biologyPharmacology
169Publications
62H-index
18.7kCitations
Publications 169
Newest
#1Dragan Milenkovic (University of Auvergne)H-Index: 32
#2Irena Krga (University of Belgrade)H-Index: 6
Last. Nathalie CastanonH-Index: 35
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Abstract null null Dietary anthocyanins may slow cognitive decline, improve cognitive performance and exert neuroprotective effects against neurodegenerative disorders. However, the underlying mechanisms of their action are not fully understood. This study investigated the effects of 12-week anthocyanin-rich bilberry extract supplementation (0.02%) on global gene expression in the hippocampus of ApoE-/- mice to help the understanding of molecular mechanisms underlying anthocyanin neuroprotective...
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#1Tatjana RuskovskaH-Index: 12
Last. E. KistanovaH-Index: 7
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Cardiometabolic disorders are among the leading causes of mortality in the human population. Dietary polyphenols exert beneficial effects on cardiometabolic health in humans. Molecular mechanisms, however, are not completely understood. Aiming to conduct in-depth integrative bioinformatic analyses to elucidate molecular mechanisms underlying the protective effects of polyphenols on cardiometabolic health, we first conducted a systematic literature search to identify human intervention studies wi...
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#1Laurent-Emmanuel Monfoulet (University of Auvergne)H-Index: 8
#2Tatjana RuskovskaH-Index: 12
Last. Dragan Milenkovic (University of Auvergne)H-Index: 32
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Flavanols are important polyphenols of the human diet with extensive demonstrations of their beneficial effects on cardiometabolic health. They contribute to preserve health acting on a large range of cellular processes. The underlying mechanisms of action of flavanols are not fully understood but involve a nutrigenomic regulation. To further capture how the intake of dietary flavanols results in the modulation of gene expression, nutrigenomics data in response to dietary flavanols obtained from...
1 CitationsSource
#1Farès MoustafaH-Index: 12
#2Loic DopeuxH-Index: 1
Last. Jeannot SchmidtH-Index: 18
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Summary Introduction Hemorrhage occurs in 7–10% of patients treated with vitamin K antagonist (VKA), with major bleeding in 1–3%. Impact of nutritional status on the bleeding risk of patients on anticoagulants is still poorly documented. Our study aimed to analyze the link between the nutritional status of patients on VKA and the occurrence of hemorrhagic events. We also analyzed micronutrients status. Methods A case–control, monocentric, and prospective study was conducted from August 2012 to O...
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Last. Dragan Milenkovic (Yale University)H-Index: 2
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Cerebral blood vessels are lined with endothelial cells and form the blood-brain barrier. Their dysfunction constitutes a crucial event in the physiopathology of neurodegenerative disorders and cognitive impairment. Epicatechin can improve cognitive functions and lower the risk for Alzheimer's disease or stroke. However, molecular mechanisms of epicatechin on brain vascular endothelium are still unexplored. The objective of this study was to investigate the biological effects of gut microbiome-d...
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#1Thomas Sinegre (INRA: Institut national de la recherche agronomique)H-Index: 6
#2Dragan Milenkovic (INRA: Institut national de la recherche agronomique)H-Index: 32
Last. Aurélien Lebreton (INRA: Institut national de la recherche agronomique)H-Index: 10
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Fibrin clot structure and function are major determinants of thromboembolic diseases. The study aim was to determine the impact of epicatechin (a flavonoid with cardiovascular protective effects) on fibrin clot structure and permeability. Plasma samples from 12 healthy subjects were incubated with increasing concentrations of epicatechin. Turbidity of fibrin clot was analyzed by absorbance measurement at 405nm. The fibrin clot nanostructure was determined by scanning spectrometry (wavelength fro...
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Last. Euclides Lara Cardozo Junior (Universidade Paranaense)H-Index: 6
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(1) Background: Due to its richness in chlorogenic acids (CGAs), Mate (Ilex paraguariensis A. St.-Hil.) could be of interest in the prevention of cardiometabolic diseases, however clinical evidence are lacking. This trial aimed to evaluate the impact of mate CGAs, consumed in a daily dose achievable through traditional mate beverages, on parameters related to cardiometabolic risk. (2) Design: Thirty-four male volunteers aged 45-65 years and with at most one criteria of metabolic syndrome, were r...
2 CitationsSource
#1Thomas SinegreH-Index: 6
#2Dragan MilenkovicH-Index: 32
Last. Aurélien LebretonH-Index: 5
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Microparticles play a role in cardiovascular disease pathology. The flavanol-like epicatechin is increasingly considered due to its cardioprotective effects. The aim of this study was to investigate the impact of epicatechin on microparticle generation, phenotype and procoagulant properties. Plasma samples from 15 healthy subjects were incubated with increasing concentrations of epicatechin (1 to 100 μM). Then, the expression of glycoprotein IIb, phosphatidylserine (PS), glycoprotein Ib (GPIb) a...
2 CitationsSource
#2Caroline BuffièreH-Index: 20
Last. Christine MorandH-Index: 62
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Food matrix interactions with polyphenols can affect their bioavailability and as a consequence may modulate their biological effects. The aim of this study was to determine if the matrix and its processing would modulate the bioavailability and the postprandial nutrigenomic response to a dietary inflammatory stress of apple flavan-3-ol monomers. We carried out an acute randomized controlled study in minipigs challenged with a high fat meal (HFM) supplemented with raw fruit, puree, or apple phen...
8 CitationsSource
#1Tatjana RuskovskaH-Index: 12
#2Marika Massaro (National Research Council)H-Index: 32
Last. Dragan Milenkovic (UC Davis: University of California, Davis)H-Index: 32
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Flavanols intake positively influences several cardiometabolic risk factors in humans. However, the specific molecular mechanisms of action of flavanols, in terms of gene regulation, in the cell types relevant to cardiometabolic disease have never been systematically addressed. On this basis, we conducted a systematic literature review and a comprehensive bioinformatic analysis of genes which expression is affected by flavanols in cells defining the cardiometabolic health: hepatocytes, adipocyte...
8 CitationsSource