T cells from induced and spontaneous models of SLE recognize a common T cell epitope on β2-glycoprotein I
Abstract
Systemic lupus erythematosus is a prototypic model for B-cell epitope spread in autoimmunity. Autoantibodies to numerous molecularly distinct self-antigens emerge in a sequential manner over several years, leading to disease manifestations. Among the earliest autoantibodies to appear are those targeting phospholipid-binding proteins, particularly β2-glycoprotein I. Notably, mice immunized with β2-glycoprotein I and lipopolysaccharide develop a...
Paper Details
Title
T cells from induced and spontaneous models of SLE recognize a common T cell epitope on β2-glycoprotein I
Published Date
Mar 23, 2018
Volume
16
Issue
8
Pages
685 - 693
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