Original paper
Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity
Abstract
Significance Davenport et al. discovered that the chimeric antigen receptor (CAR) immune synapse structure is different from the T cell receptor (TCR) synapse. The CAR immune synapse formed a disorganized pattern of Lck and more rapidly recruited lytic granules compared with the TCR. The differing immune synapse correlated with faster killing of tumor target cells and detachment from dying tumor cells by CAR-T cells. These findings provide a...
Paper Details
Title
Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity
Published Date
Feb 12, 2018
Volume
115
Issue
9