Effect of immediate and prolonged GLP‐1 receptor agonist administration on uric acid and kidney clearance: Post‐hoc analyses of four clinical trials

Aims To determine the effects of glucagon‐like peptide (GLP)‐1 receptor agonists (RA) on uric acid (UA) levels and kidney UA clearance. Material and methods This study involved post‐hoc analyses of 4 controlled clinical trials, which assessed actions of GLP‐1RA administration on kidney physiology. The immediate effects of GLP‐1RA exenatide infusion vs placebo were determined in 9 healthy overweight men (Study‐A) and in 52 overweight T2DM...