Diabetes, Obesity and Metabolism
Papers 5182
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#1Qiuhong Gong (Peking Union Medical College)H-Index: 6
#2Ping Zhang (CDC: Centers for Disease Control and Prevention)H-Index: 116
Last. Peter H. Bennett (NIH: National Institutes of Health)H-Index: 101
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AIMS The extent that pre-diabetic fasting plasma glucose (FPG) levels influence the effectiveness of lifestyle interventions in preventing type 2 diabetes (T2DM) is uncertain. We aimed to determine if the outcome of lifestyle intervention in people with impaired glucose tolerance (IGT) differs in those with normal or impaired FPG levels. METHODS Using data from the Da Qing Diabetes Prevention Outcome Study, a 30-year follow-up of a six-year randomized trial of lifestyle intervention in 576 peopl...
#1Nunzio Camerlingo (UNIPD: University of Padua)H-Index: 1
#2Martina Vettoretti (UNIPD: University of Padua)H-Index: 12
Last. Simone Del Favero (UNIPD: University of Padua)H-Index: 20
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Aims null Time-in-ranges, such as time-in-range (TIR), and time-in-tight-range (TITR), time-below-range (TBR), time-above-range (TAR), are key metrics to evaluate glucose control. The duration of the CGM datastream used to compute them affects their reliability: short observation periods result in uncertain estimates, while long trials grant precise evaluation but are associated with higher costs and organizational difficulties. In this paper we propose a mathematical link between the precision/...
#1Amy L. Clark (WashU: Washington University in St. Louis)H-Index: 11
#2Zihan Yan (WashU: Washington University in St. Louis)H-Index: 3
Last. Maria S. Remedi (WashU: Washington University in St. Louis)H-Index: 13
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AIMS Type 1 diabetes (T1D) has a strong genetic predisposition and requires an environmental trigger to initiate the beta-cell autoimmune destruction. The rate of childhood obesity has risen in parallel to the proportion of T1D, suggesting high fat diet (HFD)/obesity as potential environmental triggers for autoimmune diabetes. To explore this, non-obese diabetic (NOD) mice were subjected to HFD and monitored for development of diabetes, insulitis and beta-cell stress. MATERIALS AND METHODS Four-...
#1Fabrice BonnetH-Index: 66
#2Hungta Chen (AstraZeneca)H-Index: 10
Last. Afrah Siddiqui (AstraZeneca)
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AIMS Glycaemic control is a cornerstone of type 2 diabetes (T2D) management. We assessed factors associated with good long-term glycaemic control in patients with glycated haemoglobin (HbA1c) ≥7.0% at initiation of second-line glucose-lowering therapy, using data from DISCOVER, a global, prospective, 3-year observational study of patients with T2D. MATERIALS AND METHODS This analysis included patients with HbA1c ≥7.0% at baseline (initiation of second-line therapy). Multivariable regression mode...
#1Kirsten Dahl (Novo Nordisk)H-Index: 7
#2Tine A. Bækdal (Novo Nordisk)H-Index: 9
#1Daniel R. Quast (RUB: Ruhr University Bochum)H-Index: 2
#2Michael A. Nauck (RUB: Ruhr University Bochum)H-Index: 97
Last. Juris J. Meier (RUB: Ruhr University Bochum)H-Index: 73
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AIM To clarify the distinct effects of a long-acting (liraglutide) and a short-acting (lixisenatide) glucagon-like peptide-1 receptor agonist (GLP-1 RA) on macronutrient intake, gastrointestinal side effects and pancreas function. MATERIALS AND METHODS Fifty participants were randomized to either lixisenatide or liraglutide for a treatment period of 10 weeks. Appetite, satiety, macronutrient intake, gastrointestinal symptoms and variables related to pancreatic function and gastric emptying were ...
#1Enzo Bonora (University of Verona)H-Index: 88
#2Juan P. FriasH-Index: 26
Last. David A. Cox (Eli Lilly and Company)H-Index: 75
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AIM To evaluate the impact of dulaglutide 3.0 and 4.5 mg versus 1.5 mg on body weight in patients with type 2 diabetes (T2D) based on exploratory analyses of the AWARD-11 trial. MATERIALS AND METHODS Patients were randomized to once-weekly dulaglutide 1.5 (n = 612), 3.0 (n = 616) or 4.5 mg (n = 614) for 52 weeks. The primary objective was superiority of dulaglutide 3.0 and/or 4.5 mg over 1.5 mg in HbA1c reduction at 36 weeks. Secondary and exploratory assessments included weight reduction in the...
#1Annemie Stege Bojer (University of Southern Denmark)H-Index: 2
Last. Per Lav Madsen (UCPH: University of Copenhagen)H-Index: 23
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AIM To investigate if short-term treatment of liraglutide a glucagon-like peptide-1 receptor agonist improves left ventricular diastolic function. MATERIALS AND METHODS An investigator-initiated double-blind randomized placebo-controlled trial on the effect of 18 weeks of treatment with liraglutide on diastolic function was assessed in type 2 diabetes patients with signs of diastolic dysfunction (echo-Doppler determined E/e' ≥ 9 or/and lateral e' ≤ 10 cm/sec). Primary outcomes were improved left...
#1Yogini Chudasama (Leicester General Hospital)H-Index: 8
#2Francesco Zaccardi (Leicester General Hospital)H-Index: 33
Last. Kamlesh Khunti (Leicester General Hospital)H-Index: 96
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Objective null To investigate factors associated with delays in receiving glucose-lowering therapy in patients newly diagnosed with type 2 diabetes mellitus (T2DM), and explore the preferential order and time of intensifications. null Methods null Retrospective cohort study including 120 409 adults with T2DM initiating first to fourth-line glucose-lowering therapy in primary care between 2000 and 2018, using the UK Clinical Practice Research Datalink linked to Hospital Episode Statistics, Office...
#1Ravi Retnakaran (Lunenfeld-Tanenbaum Research Institute)H-Index: 60
#2Baiju R. ShahH-Index: 38
AIMS The elevated lifetime risk of cardiovascular disease in women who develop gestational diabetes (GDM) has been attributed to adverse life-course trajectories of cardiovascular risk factors that arise before pregnancy and continue thereafter. We hypothesized that pregnancy may differentially impact these trajectories in women who develop GDM and those who do not. METHODS With population-based administrative databases, we identified all nulliparous women in Ontario, Canada, who had singleton p...
Top fields of study
Type 2 diabetes
Diabetes mellitus