Retinal conduction speed analysis reveals different origins of the P50 and N95 components of the (multifocal) pattern electroretinogram

The pattern electroretinogram (PERG), an indicator of retinal ganglion cell (RGC) function, comprises a P50 and an N95 component. We addressed the question of whether the N95 originates, like the P50, from the RGC bodies or from the change of axon orientation at the optic nerve head (ONH). Thus, we recorded multifocal PERGs for 36 retinal locations in 21 participants. Second-order kernel responses were analyzed for the dependence of peak time...