Experimental Eye Research
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#1Shumet T. Gegnaw (CNRS: French National Centre for Scientific Research)
#2Cristina Sandu (CNRS: French National Centre for Scientific Research)H-Index: 8
Last. Marie-Paule Felder-Schmittbuhl (CNRS: French National Centre for Scientific Research)H-Index: 19
view all 5 authors...
Abstract null null The retinal circadian system consists of a network of clocks located virtually in every retinal cell-type. Although it is established that the circadian clock regulates many rhythmic processes in the retina, the links between retinal cell-specific clocks and visual function remain to be elucidated. Bmal1 is a principal, non-redundant component of the circadian clock in mammals and is required to keep 24 h rhythms in the retinal transcriptome and in visual processing under phot...
#1Wang Y (NMU: Nanjing Medical University)
#1Ying Wang (NMU: Nanjing Medical University)H-Index: 4
Last. Zhenzhen Wang (Soochow University)H-Index: 2
view all 13 authors...
Abstract null null Choroidal neovascularization (CNV), a feature of neovasular age-related macular degeneration (AMD), acts as a leading cause of vision loss in the elderly. Shikonin (SHI), a natural bioactive compound extracted from Chinese herb radix arnebiae, exerts anti-inflammatory and anti-angiogenic roles and also acts as a potential pyruvate kinase M2 (PKM2) inhibitor in macrophages. The major immune cells macrophages infiltrate the CNV lesions, where the production of pro-angiognic cyto...
#1Min Ji (Nantong University)H-Index: 5
#2Qing Sun (Nantong University)H-Index: 1
Last. Huaijin Guan (Nantong University)H-Index: 15
view all 7 authors...
Abstract null null Microglia and its interaction with Muller cells are responsible to retinal surveillance during retinal neurodegeneration, however, the role and mechanism of microglia-derived tumor necrosis factor (TNF)-α in the activation of retinal Muller cells have not been fully elucidated. In the present study, primary microglia and Muller cells were isolated from newborn Sprague-Dawley (SD) rats with purities of 88.2 ± 6.2% and 92.2 ± 2.2%, respectively. By performing immunofluorescence ...
#1Gaganpreet Kaur (LSU: Louisiana State University)H-Index: 1
#2Janet Rogers (OSU: Oklahoma State University)H-Index: 8
Last. Norman R. Harris (LSU: Louisiana State University)H-Index: 21
view all 7 authors...
Abstract null null Purpose null Diabetic retinopathy is a vision-threatening complication of diabetes characterized by endothelial injury and vascular dysfunction. The loss of the endothelial glycocalyx, a dynamic layer lining all endothelial cells, contributes to several microvascular pathologies, including an increase in vascular permeability, leukocyte plugging, and capillary occlusion, and may drive the progression of retinopathy. Previously, a significant decrease in glycocalyx thickness ha...
#1Maoren Wang (University of Cologne)
#2Marija Milic (Johannes Gutenberg University of Mainz)H-Index: 1
Last. Verena Prokosch (University of Cologne)H-Index: 6
view all 11 authors...
Abstract null null Purpose null The roles of vascular dysfunction and chronic stress have been extensively discussed in the pathophysiology of glaucoma. Our aim was to test whether chronic stress causes retinal vascular dysfunction and therewith induces retinal ganglion cells (RGCs) loss. null null null Methods null Twelve mice underwent chronic social defeat (CSD) stress, while 12 mice received control treatment only. Intraocular pressure (IOP) was measured with a rebound tonometer. Blood plasm...
#1Gaganashree Shivashankar (University of Auckland)H-Index: 2
#2Julie C. Lim (University of Auckland)H-Index: 16
Last. Monica L. Acosta (University of Auckland)H-Index: 20
view all 3 authors...
Abstract null null Diabetic retinopathy (DR) is the leading cause of vision impairment in working age adults. In addition to hyperglycemia, retinal inflammation is an important driving factor for DR development. Although DR is clinically described as diabetes-induced damage to the retinal blood vessels, several studies have reported that metabolic dysregulation occurs in the retina prior to the development of microvascular damage. The two most commonly affected metabolic pathways in diabetic con...
Abstract null null Avoiding damage of the endothelial cells, especially in thin corneas, remains a challenge in corneal collagen crosslinking (CXL). Knowledge of the riboflavin gradients and the UV absorption characteristics after topical application of riboflavin in concentrations ranging from 0.1% to 0.5% could optimize the treatment. In this study, we present a model to calculate the UV-intensity depending on the corneal thickness. null Ten groups of de-epithelialized porcine corneas were div...
#1Yuki Sugiyama (Keio University)H-Index: 9
#2Yosuke Nakazawa (Keio University)H-Index: 6
Last. Hiroomi Tamura (Keio University)H-Index: 23
view all 8 authors...
Posterior capsule opacification (PCO), the most common complication of cataract surgery occurring in 20-50% of patients after 2-5 years of cataract surgery, is a major problem in the aging society. The epithelial-mesenchymal transition (EMT) of lens epithelial cells after cataract surgery has been proposed as a major cause of PCO. Capsaicin, widely used as a food additive and analgesic agent, is a major pungent ingredient in red pepper. Although the effect of capsaicin on EMT has been reported i...
#1Kevin Choy (Duke University)
#2Guorong Li (Duke University)H-Index: 30
Last. Sina Farsiu (Duke University)H-Index: 60
view all 4 authors...
Abstract null null The purpose of this study was to develop an automatic deep learning-based approach and corresponding free, open-source software to perform segmentation of the Schlemm's canal (SC) lumen in optical coherence tomography (OCT) scans of living mouse eyes. A novel convolutional neural network (CNN) for semantic segmentation grounded in a U-Net architecture was developed by incorporating a late fusion scheme, multi-scale input image pyramid, dilated residual convolution blocks, and ...
#1Kai Wang (FJU: Fu Jen Catholic University)H-Index: 4
#2Pei-Ni Chen (CSMU: Chung Shan Medical University)H-Index: 26
Last. Shun-Fa Yang (CSMU: Chung Shan Medical University)H-Index: 68
view all 7 authors...
Abstract null null Proliferative vitreoretinopathy (PVR) involves retinal pigment epithelium (RPE) cell proliferation and migration and leads to tractional retinal detachment. Demethoxycurcumin (DMC), a curcuminoid, has anti-inflammatory and anti-tumour properties. However, whether DMC affects the migration of RPE cells and the molecular mechanism of human PVR remains unclear. The aim of the current study was to investigate the effects of DMC on the inhibition of migration and proteinase express...
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