Experimental Eye Research
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Abstract null null M-opsin, encoded by opn1mw gene, is involved in green-light perception of mice. The role of M-opsin in emmetropization of mice remains uncertain. To answer the above question, 4-week-old wild-type (WT) mice were exposed to white light or green light (460–600 nm, a peak at 510 nm) for 12 weeks. Refractive development was estimated biweekly. After treatment, retinal function was assessed using electroretinogram (ERG). Dopamine (DA) in the retina was evaluated by high-performance...
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#1Ranganathan Arunkumar (UofU: University of Utah)H-Index: 3
#2Aruna Gorusupudi (UofU: University of Utah)H-Index: 14
Last. Paul S. Bernstein (UofU: University of Utah)H-Index: 69
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Abstract null null Accumulation of bisretinoids such as A2E and its isomer iso-A2E is thought to mediate blue light-induced oxidative damage associated with age-related macular degeneration (AMD) and autosomal recessive Stargardt disease (STGD1). We hypothesize that increasing dietary intake of the macular carotenoids lutein and zeaxanthin in individuals at risk of AMD and STGD1 can inhibit the formation of bisretinoids A2E and iso-A2E, which can potentially ameliorate macular degenerative disea...
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#1Lincoln Biswas (GCU: Glasgow Caledonian University)H-Index: 9
#2Khalid S. Ibrahim (GCU: Glasgow Caledonian University)H-Index: 1
Last. Xinhua Shu (GCU: Glasgow Caledonian University)H-Index: 22
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Age-related Macular Degeneration (AMD) is a major cause of sight impairment in the elderly with complex aetiology involving genetics and environment and with limited therapeutic options which have limited efficacy. We have previously shown in a mouse-model of the condition, induced by feeding a high fat diet, that adverse effects of the diet can be reversed by co-administration of the TSPO activator, etifoxine. We extend those observations showing improvements in retinal pigment epithelial (RPE)...
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#1Lisa A. Brennan (FAU: Florida Atlantic University)H-Index: 20
#2Joshua Disatham (FAU: Florida Atlantic University)H-Index: 2
Last. Marc Kantorow (FAU: Florida Atlantic University)H-Index: 25
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A hallmark feature of lens development and differentiation is the complete elimination of organelles from the center of the eye lens. A long unanswered question in lens biology is what are the mechanisms that control the elimination of organelles during the terminal remodeling program to form mature lens fiber cells? Recent advances have expanded our understanding of these mechanisms including newly discovered signaling pathways, proteasomal regulators, autophagy proteins, transcription factors ...
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#1Kaibao Ji (WHU: Wuhan University)H-Index: 2
#2Zongyuan Li (WHU: Wuhan University)H-Index: 2
Last. Yiqiao Xing (WHU: Wuhan University)H-Index: 12
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Abstract null null Background null Resveratrol (RES) is a natural polyphenol that has been shown to protect retinal ganglion cells (RGCs) following retinal ischemia reperfusion (I/R) injury. However, the molecular mechanisms of resveratrol function are yet to be fully elucidated. Thus, this study explored the potential mechanisms of resveratrol in vivo. null null null Methods null A retinal ischemia reperfusion injury model was established in adult male C57BL/6 J mice. Intraperitoneal injection ...
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#1Azfira Hussain (SN: Sankara Nethralaya)
#2Aparna Gopalakrishnan (SN: Sankara Nethralaya)H-Index: 3
Last. Viswanathan Sivaraman (SN: Sankara Nethralaya)H-Index: 3
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The purpose of this experimental case-control study was to explore the association between myopia and concentration of dopamine and melatonin in serum and tear fluid among young myopic adults, compared to age matched non-myopic controls. Healthy myopic adults with Spherical equivalent refraction (SER) of ≤ -0.50 D to -6.00 D and emmetropic adults were included in the study. All participants underwent comprehensive eye examination and ocular biometric measures that included-axial length and corne...
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#1Guadalupe Álvarez-Hernán (University of Extremadura)H-Index: 5
#2Sergio Garrido-Jimenez (University of Extremadura)H-Index: 2
Last. Javier Francisco-Morcillo (University of Extremadura)H-Index: 14
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Abstract null null Planar cell polarity (PCP) is evolutionary conserved and play a critical role in proper tissue development and function. During central nervous system development, PCP proteins exhibit specific patterns of distribution and are indispensable for axonal growth, dendritogenesis, neuronal migration, and neuronal differentiation. The retina constitutes an excellent model in which to study molecular mechanisms involved in neural development. The analysis of the spatiotemporal expres...
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#1Wei Zhang (Tianjin Medical University)H-Index: 2
#2Han Han (Tianjin Medical University General Hospital)
Abstract null null The purpose of this study was to investigate whether excessive extracellular matrix (ECM) deposition-induced mechanical matrix stiffness plays a key role in promoting retinal pigment epithelial (RPE) cell activation and the subsequent development of proliferative vitreoretinopathy (PVR). Human ARPE-19 cells were cultured on either 50 kappa (stiff) or 0.5 kappa (soft) gel-coated coverslips. Reverse and knockdown experiments were carried out to establish a model of matrix stiffn...
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#1Lakshmi Rajagopalan (DuPont)H-Index: 3
#2Corine Ghosn (DuPont)
Last. Michael Engles (DuPont)H-Index: 1
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Abstract null null Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD) characterized by atrophy of the retinal pigment epithelium (RPE), loss of photoreceptors, and disruption of choriocapillaris. Excessive light exposure is toxic to the retina and is a known risk factor for AMD. We first investigated the effects of blue light-induced phototoxicity on RPE and photoreceptors in nonhuman primates (NHPs, a model of progressive retinal degeneration) and then evaluat...
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#1Kevin L. Schey (Vandy: Vanderbilt University)H-Index: 53
#2Zhen Wang (Vandy: Vanderbilt University)H-Index: 109
Last. Roger J.W. Truscott (Illawarra Health & Medical Research Institute)H-Index: 59
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Abstract null null Although protein crosslinking is often linked with aging as well as some age-related diseases, very few molecular details are available on the nature of the amino acids involved, or mechanisms that are responsible for crosslinking. Recent research has shown that several amino acids are able to generate reactive intermediates that ultimately lead to covalent crosslinking through multiple non-enzymatic mechanisms. This information has been derived from proteomic investigations o...
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