FTO reduces mitochondria and promotes hepatic fat accumulation through RNA demethylation

Fat mass and obesity‐associated protein (FTO) is a RNA demethylase, whether FTO regulates fat metabolism through its demethylation is unclear. The results of this study confirmed that N6‐methyladenosine (m 6 A) is associated with fat accumulation both in vivo and in vitro. The data showed that FTO down‐regulated m 6 A levels, decreased mitochondrial content, and increased triglyceride (TG) deposition. However, an FTO (R316A) mutant lacking...