Journal of Cellular Biochemistry
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#1Hiroko Teshima (Kyoto Pharmaceutical University)H-Index: 1
#2Hiroko Watanabe (Kyoto Pharmaceutical University)
Last. Youhei Saito (Kyoto Pharmaceutical University)H-Index: 16
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The mammalian HSP105/110 family consists of four members, including Hsp105 and Apg-1, which function as molecular chaperones. Recently, we reported that Hsp105 knockdown increases sensitivity to the DNA-damaging agent Adriamycin but decreases sensitivity to the microtubule-targeting agent paclitaxel. However, whether the other Hsp105/110 family proteins have the same functional property is unknown. Here, we show that Apg-1 has different roles from Hsp105 in cell proliferation, cell division, and...
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#1Mahmood Hassan Dalhat (KAU: King Abdulaziz University)H-Index: 1
#2Mohammed Razeeth Shait Mohammed (KAU: King Abdulaziz University)H-Index: 2
Last. Hani Choudhry (KAU: King Abdulaziz University)H-Index: 23
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Remodelin is a small molecule inhibitor of N-acetyltransferase 10 (NAT10), reported to reverse the effect of cancer conditions such as epithelial to mesenchymal transition, hypoxia, and drug resistance. We analysed RNA seq data of siNAT10 and found many metabolic pathways were altered, this made us perform unbiased metabolic analysis. Here we performed untargeted metabolomics in Remodelin treated cancer cells using high-performance liquid chromatography-tandem mass spectrometry. Statistical anal...
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#1Aniket Naha (VIT University)H-Index: 2
#2Saranya Vijayakumar (Christian Medical College & Hospital)H-Index: 5
Last. Anand Anbarasu (VIT University)H-Index: 17
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Emerging nosocomial strains of Acinetobacter baumannii are of recent concern as they are expressing extensive drug resistance (XDR). Using whole-genome sequencing and molecular characterisation analysis, the current study reveals the presence of carbapenemase genes in 92.86% of studied Indian isolates. These included blaOXA-51 , blaOXA-23 , blaOXA-58 , and blaNDM genes, with over a third expressing dual carbapenemase genes. As per the MLST scheme, IC2Oxf /CC2Pas was the predominant clone, with 5...
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#1Luciana Chain Veronez (USP: University of São Paulo)H-Index: 5
#2Pablo Ferreira das Chagas (USP: University of São Paulo)H-Index: 2
Last. Carlos Alberto Scrideli (USP: University of São Paulo)H-Index: 25
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Adrenocortical carcinoma (ACC) is a rare, but highly aggressive cancer of the adrenal cortex with a generally poor prognosis. Despite being rare, completely resected ACCs present a high risk of recurrence. Musashi-2 (MSI2) has recently been recognized as a potential prognostic biomarker and therapeutic target in many cancers. However, no studies have evaluated the clinical significance of MSI2 expression in ACC. Here, we addressed MSI2 expression and its association with ACC prognosis and clinic...
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#1Fatemeh Forouzanfar (MUMS: Mashhad University of Medical Sciences)H-Index: 11
#2Mostafa Soleimannejad (Shahrekord University of Medical Sciences)H-Index: 4
Last. Samira Asgharzade (Shahrekord University of Medical Sciences)H-Index: 7
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Degeneration and apoptotic death of the photoreceptor cell-layer of retina are a major cause of irreversible blindness in the development era. The stem cell replacement therapy is one of the strategies for the retinal repairing. In addition, exogenous signals critically contribute to the direction of lineage decisions that causes the fate-restricted photoreceptor progenitors from stem cell progeny in culture. It has been found that epidermal growth factor (EGF), taurine, and retinoic acid (RA) i...
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#1Priyanka Chaudhary (JNU: Jawaharlal Nehru University)H-Index: 1
#2Shweta Sharma (JNU: Jawaharlal Nehru University)H-Index: 1
Last. Ranjana Arya (JNU: Jawaharlal Nehru University)H-Index: 8
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Accumulation of misfolded proteins in endoplasmic reticulum (ER) generates a stress condition in the cell. The cell combats ER stress by activating unfolded protein response (UPR) and ERAD (ER stress-associated degradation) pathway. Failure to restore favorable folding environment results in cell dysfunction and apoptosis. Various neurodegenerative disorders are characterized by the accumulation of misfolded protein, protein aggregates, and ER stress. GNE myopathy (GNEM) is a neuromuscular disor...
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#1Jéssica M. M. Valadares (UFSJ: Universidade Federal de São João del-Rei)H-Index: 3
#2Sumit O. Bajaj (NU: Northeastern University)H-Index: 4
Last. François Noël (UFRJ: Federal University of Rio de Janeiro)H-Index: 22
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Cardiac glycosides, such as digoxin and digitoxin, are compounds that interact with Na+ /K+ -ATPase to induce anti-neoplastic effects; however, these cardiac glycosides have narrow therapeutic index. Thus, semi-synthetic analogs of digitoxin with modifications in the sugar moiety has been shown to be an interesting approach to obtain more selective and more effective analogs than the parent natural product. Therefore, the aim of this study was to assess the cytotoxic potential of novel digitoxig...
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#1Kuan Ho Lin (China Medical University (Taiwan))H-Index: 11
#2Shang-Chuan Ng (China Medical University (Taiwan))H-Index: 1
Last. Wei Wen Kuo (China Medical University (Taiwan))H-Index: 33
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Hyperglycemia results in the formation of reactive oxygen species which in turn causes advanced glycation end products (AGEs) formation, leading to diabetic cardiomyopathy. Our previous study showed that AGE-induced reactive oxygen species-dependent apoptosis is mediated via protein kinase C delta (PKCδ)-enhanced mitochondrial damage in cardiomyocytes. By using microRNA (miRNA) database, miRNA-210 was predicted to target c-Jun N-terminal kinase (JNK), which were previously identified as downstre...
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#1Ankur Rakesh Dubey (Indian Institute of Technology, Jodhpur)H-Index: 1
#2Yuvraj Anandrao Jagtap (Indian Institute of Technology, Jodhpur)
Last. Amit Mishra (Indian Institute of Technology, Jodhpur)H-Index: 32
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Viruses are known to cause various diseases in human and also infect other species such as animal plants, fungi, and bacteria. Replication of viruses depends upon their interaction with hosts. Human cells are prone to such unwanted viral infections. Disintegration and reconstitution require host machinery and various macromolecules like DNA, RNA, and proteins are invaded by viral particles. E3 ubiquitin ligases are known for their specific function, that is, recognition of their respective subst...
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#1Eileen Socher (FAU: University of Erlangen-Nuremberg)H-Index: 8
#2Marcus Conrad (FAU: University of Erlangen-Nuremberg)H-Index: 2
Last. Philipp Arnold (FAU: University of Erlangen-Nuremberg)H-Index: 13
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Variants of concern of the SARS-CoV-2 virus with an asparagine-to-tyrosine substitution at position 501 (N501Y) in the receptor-binding domain (RBD) show enhanced infectivity compared to wild-type, resulting in an altered pandemic situation in affected areas. These SARS-Cov-2 variants comprise the two Alpha variants (B.1.1.7, United Kingdom and B.1.1.7 with the additional E484K mutation), the Beta variant (B.1.351, South Africa), and the Gamma variant (P.1, Brazil). Understanding the binding mod...
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