SUMO targets the APC/C to regulate transition from metaphase to anaphase

Volume: 9, Issue: 1
Published: Mar 16, 2018
Abstract
Signal transduction by small ubiquitin-like modifier (SUMO) regulates a myriad of nuclear processes. Here we report on the role of SUMO in mitosis in human cell lines. Knocking down the SUMO conjugation machinery results in a delay in mitosis and defects in mitotic chromosome separation. Searching for relevant SUMOylated proteins in mitosis, we identify the anaphase-promoting complex/cyclosome (APC/C), a master regulator of metaphase to anaphase...
Paper Details
Title
SUMO targets the APC/C to regulate transition from metaphase to anaphase
Published Date
Mar 16, 2018
Volume
9
Issue
1
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