Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice

•The diurnal variation of acetaminophen induced acute liver injury is dependent on gut microbiota. •Gut microbiota derived PPD played the key role in the diurnal variation of acetaminophen induced hepatotoxicity. •PPD participated in liver damage development by directly depleting hepatic glutathione levels. Background & Aims Acetaminophen (APAP) induced hepatotoxicity is a leading cause of acute liver failure worldwide. It is well established...