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Original paper

Molecular mechanism of ATP versus GTP selectivity of adenylate kinase

Volume: 115, Issue: 12, Pages: 3012 - 3017
Published: Mar 5, 2018
Abstract
Enzymatic substrate selectivity is critical for the precise control of metabolic pathways. In cases where chemically related substrates are present inside cells, robust mechanisms of substrate selectivity are required. Here, we report the mechanism utilized for catalytic ATP versus GTP selectivity during adenylate kinase (Adk) -mediated phosphorylation of AMP. Using NMR spectroscopy we found that while Adk adopts a catalytically competent and...
Paper Details
Title
Molecular mechanism of ATP versus GTP selectivity of adenylate kinase
Published Date
Mar 5, 2018
Volume
115
Issue
12
Pages
3012 - 3017
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