Review paper
Targeting the replication stress response in cancer
Abstract
Many conventional chemotherapies used in cancer treatment exert their effect by inflicting DNA damage. Highly proliferative tissues, as well as tumour cells, are particularly vulnerable to this damage resulting in unwanted toxicities. In contrast, a targeted therapeutic approach has the aim of specifically eliminating cancer cells but with a reduced effect on healthy tissue. New therapies have been developed that target the replication stress...
Paper Details
Title
Targeting the replication stress response in cancer
Published Date
Aug 1, 2018
Journal
Volume
188
Pages
155 - 167
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Notes
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