Short-chain fatty acids induce tissue plasminogen activator in airway epithelial cells via GPR41&43

Summary Background Chronic rhinosinusitis ( CRS ) is a heterogeneous chronic inflammatory disease generally divided based on the presence or absence of nasal polyps ( NP s). One of the features of NP s is excessive fibrin deposition, which is associated with down‐regulation of tissue plasminogen activator (t‐ PA ) in NP s. As t‐ PA is expressed in epithelial cells, and epithelium is readily accessible to topical therapies, identifying compounds...