Intramural Metastasis as a Risk Factor for Recurrence in Esophageal Squamous Cell Carcinoma.

Published on Jul 1, 2018in The Annals of Thoracic Surgery3.639
· DOI :10.1016/J.ATHORACSUR.2018.02.018
Duk Hwan Moon5
Estimated H-index: 5
Jae Hyun Jeon5
Estimated H-index: 5
+ 5 AuthorsGeon Kook Lee31
Estimated H-index: 31
Background The purpose of this study was to assess the clinicopathologic implications of intramural metastasis (IM) in patients with esophageal squamous cell carcinoma (ESCC). Methods We retrospectively analyzed 743 patients who underwent esophagectomy. Among these patients, IM was detected in 41 patients (5.5%). The clinicopathologic features of IM and its influence on postoperative recurrence were investigated. Results In total, 710 male patients and 33 female patients with a mean age of 64.4 ± 7.7 years were included. The median follow-up period was 98.5 months. IM was associated with large tumor size ( p p p p p p p  = 0.002) were independent risk factors for recurrence. The 5-year recurrence-free survival was 6.1% for patients with IM and 43.5% for patients without IM ( p Conclusions IM could be an important prognostic factor, along with anatomic determinants such as the TNM staging system, in patients with ESCC. Effective preoperative evaluation and postoperative surveillance may help improve the outcome of patients with ESCC, particularly when accompanied by IM.
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