Original paper

Mechanism of ubiquitin transfer promoted by TRAF6

Volume: 115, Issue: 8, Pages: 1783 - 1788
Published: Feb 5, 2018
Abstract
Significance Polyubiquitination is critically important for many cellular functions from protein degradation to signal transduction. TNF receptor-associated factor 6 (TRAF6) is a RING-type ubiquitin ligase that promotes polyubiquitination required for the signaling of many innate immune receptors. How TRAF6 uses its RING dimer to facilitate polyubiquitination remains elusive. In this paper, we mapped TRAF6 residues on both subunits of the TRAF6...
Paper Details
Title
Mechanism of ubiquitin transfer promoted by TRAF6
Published Date
Feb 5, 2018
Volume
115
Issue
8
Pages
1783 - 1788
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