Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

The structure of the glucagon-like peptide 1 receptor (GLP-1R) with its biased agonist exendin-P5 sheds light on both receptor activation and the mechanism of biased agonism. The glucagon-like peptide 1 receptor (GLP-1R) is a key target for the treatment of type 2 diabetes and obesity. Recently, biased agonists—ligands that selectively activate primarily one signalling pathway—have been identified. One of these, exendin-P5, is biased for...