Methyltransferases of gentamicin biosynthesis

Volume: 115, Issue: 6, Pages: 1340 - 1345
Published: Jan 22, 2018
Abstract
Gentamicin C complex from Micromonospora echinospora remains a globally important antibiotic, and there is revived interest in the semisynthesis of analogs that might show improved therapeutic properties. The complex consists of five components differing in their methylation pattern at one or more sites in the molecule. We show here, using specific gene deletion and chemical complementation, that the gentamicin pathway up to the branch point is...
Paper Details
Title
Methyltransferases of gentamicin biosynthesis
Published Date
Jan 22, 2018
Volume
115
Issue
6
Pages
1340 - 1345
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