Original paper
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
Abstract
Mitochondrial apoptosis is mediated by BAK and BAX, two proteins that induce mitochondrial outer membrane permeabilization, leading to cytochrome c release and activation of apoptotic caspases. In the absence of active caspases, mitochondrial DNA (mtDNA) triggers the innate immune cGAS/STING pathway, causing dying cells to secrete type I interferon. How cGAS gains access to mtDNA remains unclear. We used live-cell lattice light-sheet microscopy...
Paper Details
Title
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
Published Date
Feb 23, 2018
Journal
Volume
359
Issue
6378
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Notes
History