Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding

Volume: 9, Issue: 1
Published: Feb 6, 2018
Abstract
Collagen lysyl hydroxylases (LH1-3) are Fe2+- and 2-oxoglutarate (2-OG)-dependent oxygenases that maintain extracellular matrix homeostasis. High LH2 levels cause stable collagen cross-link accumulations that promote fibrosis and cancer progression. However, developing LH antagonists will require structural insights. Here, we report a 2 Å crystal structure and X-ray scattering on dimer assemblies for the LH domain of L230 in Acanthamoeba...
Paper Details
Title
Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
Published Date
Feb 6, 2018
Volume
9
Issue
1
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