Multidimensional endotypes of chronic rhinosinusitis and their association with treatment outcomes

Background The expression of chronic rhinosinusitis ( CRS ) is multidimensional. Disease heterogeneity in patients with CRS remains poorly understood. This study aimed to identify endotypes of CRS using cluster analysis by integrating multidimensional characteristics and to explore their association with treatment outcomes. Methods A total of 28 clinical variables and 39 mucosal cellular and molecular variables were analyzed using principal...