An Animal Model of Abacavir-Induced HLA-Mediated Liver Injury
Abstract
Genome-wide association studies indicate that several idiosyncratic adverse drug reactions are highly associated with specific human leukocyte antigen (HLA) alleles. For instance, abacavir, a human immunodeficiency virus reverse transcriptase inhibitor, induces multiorgan toxicity exclusively in patients carrying the HLA-B*57:01 allele. However, the underlying mechanism is unclear due to a lack of appropriate animal models. Previously, we...
Paper Details
Title
An Animal Model of Abacavir-Induced HLA-Mediated Liver Injury
Published Date
Jan 8, 2018
Journal
Volume
162
Issue
2
Pages
713 - 723
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