Pulmonary 18F-FDG uptake helps refine current risk stratification in idiopathic pulmonary fibrosis (IPF).

Published on Jan 16, 2018in European Journal of Nuclear Medicine and Molecular Imaging7.081
· DOI :10.1007/S00259-017-3917-8
Thida Win27
Estimated H-index: 27
(Lister Hospital),
Nicholas Screaton28
Estimated H-index: 28
(Papworth Hospital)
+ 14 AuthorsAshley M. Groves48
Estimated H-index: 48
(UCLH: University College Hospital)
Sources
Abstract
Purpose There is a lack of prognostic biomarkers in idiopathic pulmonary fibrosis (IPF) patients. The objective of this study is to investigate the potential of 18F-FDG-PET/ CT to predict mortality in IPF.
📖 Papers frequently viewed together
2007
8 Authors (Bom Sahn Kim, ..., Myung-Chul Lee)
8 Citations
38 Citations
References42
Newest
#1Stephen M. Humphries (University of Colorado Denver)H-Index: 14
#2Kunihiro Yagihashi (St. Marianna University School of Medicine)H-Index: 17
Last. David A. Lynch (University of Colorado Denver)H-Index: 124
view all 11 authors...
Our findings that data-driven textural analysis fibrosis score is associated with baseline measures of disease severity and with change over time suggest that CT captures anatomic information that can be quantified by using automatic computational methods to provide useful indexes of disease severity and progression in patients with idiopathic pulmonary fibrosis.
58 CitationsSource
#1Paolo Spagnolo (UNIPD: University of Padua)H-Index: 31
#2Toby M. Maher (NIHR: National Institute for Health Research)H-Index: 66
15 CitationsSource
#1Aurélien Justet (Paris Diderot University)H-Index: 8
Last. Bruno Crestani (Paris Diderot University)H-Index: 25
view all 9 authors...
Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by an unpredictable course. Prognostic markers and disease activity markers are needed. The purpose of this single-center retrospective study was to evaluate the prognostic value of lung fluorodeoxyglucose ([18F]-FDG) uptake assessed by standardized uptake value (SUV), metabolic lung volume (MLV) and total lesion glycolysis (TLG) in patients with IPF.
38 CitationsSource
#1Delphine L. Chen (WashU: Washington University in St. Louis)H-Index: 21
#2Joseph Cheriyan (University of Cambridge)H-Index: 20
Last. Frederick J. Wilson (GSK: GlaxoSmithKline)H-Index: 4
view all 23 authors...
Millions of people are affected by respiratory diseases, leading to a significant health burden globally. Due to the current insufficient knowledge of the underlying mechanisms that lead to the development and progression of respiratory diseases, treatment options remain limited. To overcome this limitation and understand the associated molecular changes, non-invasive imaging techniques such as positron emission tomography (PET) and single photon emission computed tomography have been explored f...
34 CitationsSource
#1Joseph JacobH-Index: 23
#2Brian J. Bartholmai (Mayo Clinic)H-Index: 33
Last. David M. HansellH-Index: 97
view all 9 authors...
Computer-based computed tomography (CT) analysis can provide objective quantitation of disease in idiopathic pulmonary fibrosis (IPF). A computer algorithm, CALIPER, was compared with conventional CT and pulmonary function measures of disease severity for mortality prediction. CT and pulmonary function variables (forced expiratory volume in 1 s, forced vital capacity, diffusion capacity of the lung for carbon monoxide, transfer coefficient of the lung for carbon monoxide and composite physiologi...
116 CitationsSource
#1Mahefatiana Andrianifahanana (Mayo Clinic)H-Index: 9
#2Danielle M. Hernandez (Mayo Clinic)H-Index: 5
Last. Edward B. Leof (Mayo Clinic)H-Index: 48
view all 10 authors...
TGF-β plays a central role in the pathogenesis of fibroproliferative disorders. Defining the exact underlying molecular basis is therefore critical for the development of viable therapeutic strateg...
31 CitationsSource
#1Tomomi Nobashi (Kyoto University)H-Index: 9
#2Takeshi Kubo (Kyoto University)H-Index: 20
Last. Kaori Togashi (Kyoto University)H-Index: 84
view all 8 authors...
This study evaluated the clinical significance of 18F-FDG PET/CT in patients with interstitial lung disease (ILD), by investigating the relationships between 18F-FDG PET/CT parameters and clinical indicators and by evaluating the prognostic implications of 18F-FDG PET/CT results.Ninety patients (51 men, 39 women; mean age, 55.4 y; age range, 26-78 y) with ILD who underwent 18F-FDG PET/CT were retrospectively analyzed. SUVmean was defined as the mean SUV of the less-affected lung field, SUVTF as ...
13 CitationsSource
#1Jung Won Moon (SKKU: Sungkyunkwan University)H-Index: 5
#2Jang Pyo Bae (UOU: University of Ulsan)H-Index: 5
Last. Kyung Soo Lee (SKKU: Sungkyunkwan University)H-Index: 31
view all 9 authors...
Objectives To evaluate automated texture-based segmentation of dual-energy CT (DECT) images in diffuse interstitial lung disease (DILD) patients and prognostic stratification by overlapping morphologic and perfusion information of total lung.
18 CitationsSource
#1Jan BuceriusH-Index: 24
#2Fabien Hyafil (TUM: Technische Universität München)H-Index: 32
Last. Marcus HackerH-Index: 36
view all 10 authors...
Cardiovascular diseases are the leading cause of death not only in Europe but also in the rest of the World. Preventive measures, however, often fail and cardiovascular disease may manifest as an acute coronary syndrome, stroke or even sudden death after years of silent progression. Thus, there is a considerable need for innovative diagnostic and therapeutic approaches to improve the quality of care and limit the burden of cardiovascular diseases. During the past 10 years, several retrospective ...
115 CitationsSource
#1Beverley F. Holman (UCLH: University College Hospital)H-Index: 7
#2Vesna Cuplov (UCLH: University College Hospital)H-Index: 5
Last. Kris Thielemans (UCLH: University College Hospital)H-Index: 36
view all 5 authors...
Accurate PET quantitation requires a matched attenuation map. Obtaining matched CT attenuation maps in the thorax is difficult due to the respiratory cycle which causes both motion and density changes. Unlike with motion, little attention has been given to the effects of density changes in the lung on PET quantitation. This work aims to explore the extent of the errors caused by pulmonary density attenuation map mismatch on dynamic and static parameter estimates. Dynamic XCAT phantoms were utili...
20 CitationsSource
Cited By25
Newest
#1Brintha Selvarajah (UCL: University College London)H-Index: 2
#2Ilan Azuelos (UCL: University College London)H-Index: 2
Last. Rachel C. Chambers (UCL: University College London)H-Index: 50
view all 0 authors...
Fibrosis is the final pathological outcome and major cause of morbidity and mortality in many common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the growing incidence of fibrotic diseases and extensive research efforts, there remains a lack of effective therapies that improve survival. The application of omics technologies has revolutionized our approach to identifying previously unknown therapeutic targets and potential disease biomarkers. The application of metab...
Source
#1Matthew Nayor (BU: Boston University)H-Index: 15
#2Li Shen (UPenn: University of Pennsylvania)
Last. Paul S. de Vries (University of Texas Health Science Center at Houston)H-Index: 25
view all 18 authors...
Imaging genomics is a rapidly evolving field that combines state-of-the-art bioimaging with genomic information to resolve phenotypic heterogeneity associated with genomic variation, improve risk prediction, discover prevention approaches, and enable precision diagnosis and treatment. Contemporary bioimaging methods provide exceptional resolution generating discrete and quantitative high-dimensional phenotypes for genomics investigation. Despite substantial progress in combining high-dimensional...
Source
In recent months, much of the scientific efforts have focused on research on SARSCoV-2 infection and its consequences in humans. Still, many aspects remain unknown. It is known that the damage caused by SARS-CoV-2 is multifactorial and that its extension goes beyond lung inflammation and the acute phase, with the appearance of numerous complications and sequelae. To date, knowledge about the usefulness of 18F-FDG-PET/CT in the acute phase has been limited to the incidental detection of SARS-CoV-...
Source
Resumen null null Durante los ultimos meses gran parte de los esfuerzos cientificos se han centrado en la investigacion sobre el SARS-CoV-2 y las consecuencias de su infeccion en humanos. Aun asi, muchos aspectos siguen siendo desconocidos. Se sabe que la afectacion por SARS-CoV-2 es multifactorial y que su extension va mas alla del dano pulmonar y del momento agudo, con aparicion de numerosas de complicaciones y secuelas. El conocimiento de la utilidad de la 18F-FDG-PET/TC en el momento agudo s...
Source
#1Hyung Ju Lee (Hallym University)
#2Hye Joo Son (DU: Dankook University)
Last. Suk Hyun Lee (Hallym University)
view all 7 authors...
2-Deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron-emission tomography/computed tomography (PET/CT) is widely used to evaluate lung nodules, although respiratory motion artefacts may occur. We investigated the value of prone position PET/CT (pPET/CT) in lung nodule evaluation compared with standard supine position PET/CT (sPET/CT). We retrospectively reviewed 28 consecutive patients (20 men; age, 65.6 ± 12.1 years) with a lung nodule (size, 16.8 ± 5.5 mm) located below the sub-carinal level who...
Source
#1Robert B. Hamanaka (U of C: University of Chicago)H-Index: 29
#2Gökhan M. Mutlu (U of C: University of Chicago)H-Index: 54
Fibrosis is a pathologic condition characterized by excessive deposition of extracellular matrix and chronic scaring that can affect every organ system. Organ fibrosis is associated with significant morbidity and mortality, contributing to as many as 45% of all deaths in the developed world. In the lung, many chronic lung diseases may lead to fibrosis, the most devastating being idiopathic pulmonary fibrosis (IPF), which affects approximately 3 million people worldwide and has a median survival ...
Source
#1Steven L. Brody (WashU: Washington University in St. Louis)H-Index: 49
#2Sean P. Gunsten (WashU: Washington University in St. Louis)H-Index: 12
Last. Yongjian Liu (WashU: Washington University in St. Louis)H-Index: 4
view all 27 authors...
RATIONALE Idiopathic pulmonary fibrosis (IPF) is a progressive, inflammatory lung disease without effective molecular markers of disease activity or treatment responses. Monocyte and interstitial macrophages that express the C-C motif chemokine receptor 2 (CCR2) are active in IPF and central to fibrosis. OBJECTIVES To phenotype patients with IPF for potential targeted therapy, we developed 64Cu-DOTA-ECL1i, a radiotracer to non-invasively track CCR2+ monocytes and macrophages, using positron emis...
7 CitationsSource
#1Delphine L. Chen (UW: University of Washington)H-Index: 1
#1Delphine L. Chen (UW: University of Washington)H-Index: 1
Last. Tilo Winkler (Harvard University)H-Index: 27
view all 34 authors...
Positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) has been increasingly applied, predominantly in the research setting, to study drug effects and pulmonary biology and monitor disease progression and treatment outcomes in lung diseases, disorders that interfere with gas exchange through alterations of the pulmonary parenchyma, airways and/or vasculature. To date, however, there are no widely accepted standard acquisition protocols and imaging data analysis methods for pulm...
1 CitationsSource
#1Ryogo MinamimotoH-Index: 24
#2Masatoshi HottaH-Index: 6
Last. Takeshi InagakiH-Index: 2
view all 4 authors...
Following a lot of reports of coronavirus disease 2019 (COVID-19) CT images, the feature of FDG-PET/ CT imaging of COVID-19 was reported in several articles. Since FDG accumulates in activated inflammatory cells, FDG-PET/CT has huge potential for diagnosing and monitoring of inflammatory disease. However, FDG-PET/CT cannot be routinely used in an emergency setting and is not generally recommended as a first choice for diagnosis of infectious diseases. In this review, we demonstrate FDG-PET/CT im...
5 CitationsSource
#1Francesca Ruscitti (Chiesi Farmaceutici S.p.A.)H-Index: 4
#2Francesca Ravanetti (University of Parma)H-Index: 15
Last. Franco Fabio Stellari (Chiesi Farmaceutici S.p.A.)H-Index: 3
view all 12 authors...
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive degenerative lung disease leading to respiratory failure and death. Although anti-fibrotic drugs are now available for treating IPF, their clinical efficacy is limited and lung transplantation remains the only modality to prolong survival of IPF patients. Despite its limitations, the bleomycin (BLM) animal model remains the best characterized experimental tool for studying disease pathogenesis and assessing efficacy of novel potential ...
4 CitationsSource