Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation

Volume: 69, Issue: 1, Pages: 62 - 74.e4
Published: Jan 1, 2018
Abstract
Alternative mRNA processing is a critical mechanism for proteome expansion and gene regulation in higher eukaryotes. The SR family proteins play important roles in splicing regulation. Intriguingly, mammalian genomes encode many poorly characterized SR-like proteins, including subunits of the mRNA 3′-processing factor CFIm, CFIm68 and CFIm59. Here we demonstrate that CFIm functions as an enhancer-dependent activator of mRNA 3′ processing. CFIm...
Paper Details
Title
Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation
Published Date
Jan 1, 2018
Volume
69
Issue
1
Pages
62 - 74.e4
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