Original paper
Multimode drug inducible CRISPR/Cas9 devices for transcriptional activation and genome editing
Abstract
Precise investigation and manipulation of dynamic biological processes often requires molecular modulation in a controlled inducible manner. The clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) has emerged as a versatile tool for targeted gene editing and transcriptional programming. Here, we designed and vigorously optimized a series of Hybrid drug Inducible CRISPR/Cas9 Technologies (HIT)...
Paper Details
Title
Multimode drug inducible CRISPR/Cas9 devices for transcriptional activation and genome editing
Published Date
Nov 27, 2017
Journal
Volume
46
Issue
5
Pages
e25 - e25