Comparison of clinicopathological features in incidental and nonincidental papillary thyroid carcinomas in 308 patients.

Published on Nov 30, 2017in Polish Journal of Pathology1.072
· DOI :10.5114/PJP.2017.71527
Nuray Can9
Estimated H-index: 9
,
Filiz Ozyilmaz10
Estimated H-index: 10
+ 7 AuthorsSibel Guldiken16
Estimated H-index: 16
Sources
Abstract
: Incidental papillary thyroid carcinomas (IPTCs) consist of a significant portion of increasing incidence in papillary thyroid carcinomas. This study investigated the clinicopathological features of IPTCs from different perspectives and by comparing nonincidental PTCs (NIPTCs) in patients who underwent total thyroidectomy and lymph node dissection. Basic results were as follows. IPTC was present in 27.9% of 308 patients. IPTCs were significantly accompanied by lymphocytic thyroiditis (LT), particularly, multinodular hyperplasia (MNH). IPTCs were more common in older patients (51.3 years vs. 47.2 years) and in female patients. IPTCs significantly differed from NIPTCs in terms of smaller tumour size, lymphatic vessel invasion (2.6% vs. 97.4%), extrathyroidal extension (4.3% vs. 95.7%), lymph node metastasis (3.6% vs. 96.4%), multifocality (21.2% vs. 78.8%), bilaterality (5.3% vs. 94.7%), and BRAFV600 mutation (6.7% vs. 93.3%). Older age, bilaterality, encapsulation, and radioactive iodine (RAI) were significantly more common in IPTCs > 5 mm than in those ≤ 5 mm. In conclusion, IPTCs are more commonly associated with LT and MNH. IPTCs may have a more favourable prognosis than NIPTCs, and tumour size > 5 mm may predict bilaterality and need for RAI. Nevertheless, the patient-based clinical approach in IPTCs may have benefits in the management of IPTCs.
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#1Berna EvranosH-Index: 6
#2Sefika Burcak Polat (Yıldırım Beyazıt University)H-Index: 10
Last. Bekir Cakir (Yıldırım Beyazıt University)H-Index: 25
view all 9 authors...
INTRODUCTION: The incidence of thyroid cancer is increasing which can be attributed in part to improved ultrasonography (US) methods and increased detection of incidental thyroid carcinomas (ITC). We aimed to compare ITC with nonincidental thyroid carcinomas (NITC) in this study. METHODS: Retrospective analyses of 906 individual patients who were operated for benign and malignant thyroid disease and had a final histopathological diagnosis of thyroid carcinoma were enrolled in this study. Preoper...
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#1Kennichi Kakudo (Kindai University)H-Index: 34
#2Andrey BychkovH-Index: 17
Last. Chan Kwon Jung (CUA: The Catholic University of America)H-Index: 44
view all 6 authors...
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