Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis

Volume: 8, Issue: 1
Published: Dec 11, 2017
Abstract
Inactivation of the VHL (Von Hippel Lindau) tumour suppressor has long been recognised as necessary for the pathogenesis of clear cell renal cancer (ccRCC); however, the molecular mechanisms underlying transformation and the requirement for additional genetic hits remain unclear. Here, we show that loss of VHL alone results in DNA replication stress and damage accumulation, effects that constrain cellular growth and transformation. By contrast,...
Paper Details
Title
Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis
Published Date
Dec 11, 2017
Volume
8
Issue
1
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