Original paper
TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
Abstract
T helper cells that produce IL-17 (T(H)17 cells) promote autoimmunity in mice and have been implicated in the pathogenesis of human inflammatory diseases. At mucosal surfaces, T(H)17 cells are thought to protect the host from infection, whereas regulatory T (T(reg)) cells control immune responses and inflammation triggered by the resident microflora. Differentiation of both cell types requires transforming growth factor-beta (TGF-beta), but...
Paper Details
Title
TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
Published Date
Mar 26, 2008
Journal
Volume
453
Issue
7192
Pages
236 - 240
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Notes
History