HEB is required for the specification of fetal IL-17-producing γδ T cells

Volume: 8, Issue: 1
Published: Dec 8, 2017
Abstract
IL-17-producing γδ T (γδT17) cells are critical components of the innate immune system. However, the gene networks that control their development are unclear. Here we show that HEB (HeLa E-box binding protein, encoded by Tcf12) is required for the generation of a newly defined subset of fetal-derived CD73- γδT17 cells. HEB is required in immature CD24+CD73- γδ T cells for the expression of Sox4, Sox13, and Rorc, and these genes are repressed by...
Paper Details
Title
HEB is required for the specification of fetal IL-17-producing γδ T cells
Published Date
Dec 8, 2017
Volume
8
Issue
1
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