Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density
Abstract
Objectives To identify genetic determinants of susceptibility to clinical vertebral fractures, which is an important complication of osteoporosis. Methods Here we conduct a genome-wide association study in 1553 postmenopausal women with clinical vertebral fractures and 4340 controls, with a two-stage replication involving 1028 cases and 3762 controls. Potentially causal variants were identified using expression quantitative trait loci (eQTL)...
Paper Details
Title
Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density
Published Date
Nov 23, 2017
Volume
77
Issue
3
Pages
378 - 385
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