High fat diet‐induced oxidative stress blocks hepatocyte nuclear factor 4α and leads to hepatic steatosis in mice

Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease with manifestation of over‐accumulation of fat in liver. Increasing evidences indicate that NAFLD may be in part caused by malfunction of very low density lipoprotein (VLDL) secretion. Hepatocyte nuclear factor 4α (HNF4α), a nuclear receptor protein, plays an important role in sustain hepatic lipid homeostasis via transcriptional regulation of genes...