DRES-06. PRIMARY RESISTANCE TO EGFR INHIBITION IN GLIOBLASTOMA IS MEDIATED BY A TNF-JNK-Axl-ERK SIGNALING AXIS

Aberrant EGFR signaling is widespread in various forms of cancer, but EGFR inhibition seems to be primarily effective only in a subset of lung cancers that harbor EGFR activating mutations and are oncogene addicted. Most cancers with aberrant EGFR signaling are not oncogene addicted and exhibit a primary resistance to EGFR inhibition. EGFR gene amplification and mutation are common in glioblastoma (GBM), but EGFR inhibition is not effective in...