Arterially directed embolic therapy (ADET) with polyethylene glycol microspheres loaded with irinotecan for refractory liver metastases from colorectal cancer

Background: Patients with liver metastases from colorectal cancer are in 80% of cases non indicated for resection. The standard first line treatment of unresectablelivermetastases is systemic chemotherapy, however this method results in progression for 70% of patients. The indicated therapy for refractory patients is the arterially directed embolic therapy (ADET). In this study we monitored tumor response, and adverse events after ADET of...