A Case of Primary Melanoma of the Transverse Colon.

Published on Oct 26, 2017in Cureus
· DOI :10.7759/CUREUS.1803
Junaid Raja3
Estimated H-index: 3
(Yale University),
Rakesh Hegde1
Estimated H-index: 1
+ 3 AuthorsZhongqiu Zhang1
Estimated H-index: 1
Sources
Abstract
: Melanoma is among the most prevalent neoplasms diagnosed annually with the vast majority arising from a cutaneous origin. Though there are described metastases to the gastrointestinal tract, there are only rare descriptions of primary gastrointestinal melanoma. Both diagnosis and management of this unique population can be challenging given the infrequency with which it occurs. To follow is the third reported case of transverse colon primary melanoma with a description of multimodality treatment with surgery, chemotherapy, and immunotherapy.
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#2Jorge Dotto (Yale University)H-Index: 9
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Gastrointestinal involvement by malignant melanoma is predominantly a metastatic phenomenon. Although primary malignant melanoma of the gastrointestinal tract has been documented in the esophagus, stomach, small bowel, and anorectum, the incidence of primary melanoma of the colon is rare and remains controversial in most cases. We present a case of solitary malignant melanoma of the transverse colon occurring in a 64-year-old African American male patient. Complete dermatologic and ophthalmologi...
22 CitationsSource
Melanoma accounts for 1-3 per cent of all malignant tumors. Except cutaneous, other less common melanomas include, among others, those in the GI tract. However, their primary or secondary nature is often difficult to establish. Referring to the stomach, scattered cases of primary melanomas have been reported in the literature. We report a case of a man with an ulcerated sub-mucosal mass at the antrum of the stomach, manifested with dull upper abdominal pain, nausea, vomiting, fatigue and anemia....
29 CitationsSource
#1Deron J. Tessier (Mayo Clinic)H-Index: 20
#2Elizabeth J. McConnell (Mayo Clinic)H-Index: 5
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PURPOSE: Symptomatic melanoma of the colon is rare. The aim of this study was to determine the incidence, presenting signs and symptoms, and survival correlation. METHODS: A retrospective review was performed of all patients treated in Mayo Clinic facilities from 1960 to 2000 for primary and metastatic melanoma. We identified 24 patients with metastatic melanoma to the colon. RESULTS: There were 24 patients (14 males) with an average age of 60.4 years at the time of metastatic involvement. The i...
49 CitationsSource
#1Nezih Özdemir (Ankara University)H-Index: 13
#2Ayten Kayi CangirH-Index: 16
Last. Sinasi Yavuzer (Ankara University)H-Index: 7
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Oculocutaneous albinism is a rare autosomal recessive disorder characterized by general depigmentation, nystagmus, photophobia, and decreased visual acuity. Malignant melanoma is extremely rare in patients with albinism. We present a 41-year-old albino male patient, who was admitted with a suspected bronchogenic carcinoma. He underwent a pulmonary resection and the diagnosis was primary malign melanoma of the lung. The patient died of tumor recurrence in the postoperative 46th month. q 2001 Else...
26 CitationsSource
#1Sarah H. Poggi (Yale University)H-Index: 1
#2Jennifer M. McNiff (Yale University)H-Index: 53
Last. Ronald R. Salem (Yale University)H-Index: 29
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: Primary melanoma originating in the gastrointestinal tract is very rare and the majority of these tumors arise in the mucosa of the anus or rectum. A case of solitary colonic melanoma in a 79-year-old man is described with a review of pertinent literature. The surgically excised neoplasm was evaluated by routine histology and immunohistochemistry stains. Pathologic examination of the excised cecal mass revealed an 8 x 5-cm tan-pink mass with a central green-black necrotic area. Histologically,...
46 CitationsSource
#1Daniel Blecker (UPenn: University of Pennsylvania)H-Index: 3
#2Susan Abraham (UPenn: University of Pennsylvania)H-Index: 13
Last. Michael L. Kochman (UPenn: University of Pennsylvania)H-Index: 59
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Abstract OBJECTIVE: This article focuses on the clinical, diagnostic, and therapeutic aspects of malignant melanoma metastases to the gastrointestinal (GI) tract. The subject of primary malignant melanoma arising from the GI tract is also discussed. Malignant melanoma is the most common tumor metastatic to the GI tract, and can present with fairly nonspecific symptoms. METHODS: Up to 60% of patients with melanoma are found to have metastases at autopsy. Frequent GI sites of invasion include the ...
194 CitationsSource
Cited By2
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#1Motochika Endo (Okayama University)
#2Shuya Yano (Okayama University)H-Index: 25
Last. Toshiyoshi Fujiwara (Okayama University)H-Index: 63
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Targeted therapies for malignant melanoma have improved patients' prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune check...
Source
Introduction Although most colorectal malignancies are adenocarcinomas from colorectal mucosa, various types of malignant and benign tumors can develop, such as neuroendocrine tumors(NETs), gastrointestinal stromal tumors(GISTs), lymphomas, and sarcomas. Due to their extremely low incidence, little research has been conducted. The purpose was to assess incidence and compare it according to demographic factors using data from Korea National Cancer Registry. METHOD Data from the Korea National Can...
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