Glucose feeds the TCA cycle via circulating lactate.

Published on Oct 18, 2017in Nature42.778
· DOI :10.1038/NATURE24057
Sheng Hui12
Estimated H-index: 12
(Princeton University),
Jonathan M. Ghergurovich11
Estimated H-index: 11
(Princeton University)
+ 9 AuthorsJoshua D. Rabinowitz100
Estimated H-index: 100
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Abstract
Metabolic flux analysis in mice reveals that lactate often acts as the primary carbon source for the tricarboxylic acid cycle both in normal tissues and in tumour microenvironments.
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