Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25

The calcitonin/CGRP family of peptides includes calcitonin, α and β CGRP, amylin, adrenomedullin (AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist of one of two GPCRs, the calcitonin receptor (CTR) or the calcitonin receptor‐like receptor (CLR). Further diversity arises from heterodimerization of these GPCRs with one of three receptor activity‐modifying proteins (RAMPs). This gives the CGRP receptor (CLR/RAMP1), the AM 1...