Opposing effects of rheumatoid arthritis and low dose prednisolone on arginine metabolomics

The effects of low dose prednisolone on circulating markers of endothelial function, the arginine metabolites asymmetric dimethyl arginine (ADMA), mono methyl arginine (MMA), and homoarginine, are uncertain. We assessed whether patients with rheumatoid arthritis have perturbations in arginine metabolite concentrations that are reversed by low dose prednisolone.Eighteen rheumatoid arthritis patients who had not taken prednisolone for >6 months...