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#1Ahmed Ibrahim Ahmed (Houston Methodist Hospital)H-Index: 2
#2Paolo Raggi (U of A: University of Alberta)H-Index: 69
Last. Mouaz H. Al-Mallah (Houston Methodist Hospital)H-Index: 60
view all 3 authors...
#1Maxime M. Bos (LUMC: Leiden University Medical Center)H-Index: 5
#2Lina de Vries (LUMC: Leiden University Medical Center)
Last. Raymond Noordam (LUMC: Leiden University Medical Center)H-Index: 20
view all 7 authors...
BACKGROUND AND AIMS The APOE e4 genotype has a higher risk for developing coronary artery disease (CAD), but there is preliminary evidence that antioxidative lifestyle factors interact with APOE genotype on CAD risk. Here, we assessed the effect modification of physical activity, oily fish and polyunsaturated fatty acid (PUFA) intake with APOE genotype on risk of incident CAD. METHODS The present study comprised 345,659 white European participants from UK Biobank (mean age: 56.5 years, 45.7% men...
#1Luxi Wang (Wake Forest University)H-Index: 1
#2Yong-Joo Ahn (Wake Forest University)H-Index: 6
Last. Reto Asmis (Wake Forest University)H-Index: 28
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BACKGROUND AND AIMS The thiol transferase glutaredoxin 1 controls redox signaling and cellular functions by regulating the S-glutathionylation status of critical protein thiols. Here we tested the hypothesis that by derepressing the expression of glutaredoxin 1, inhibition of histone deacetylase 2 prevents nutrient stress-induced protein S-glutathionylation and monocyte dysfunction and protects against atherosclerosis. METHODS Using both a pharmacological inhibitor and shRNA-mediated knockdown o...
#1Yara Abou Khalil (""St. Joe's"": Saint Joseph's University)H-Index: 1
#2Jean-Pierre Rabès (French Institute of Health and Medical Research)H-Index: 27
Last. Mathilde Varret (University of Paris)H-Index: 17
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Apolipoprotein E (apoE) is a major apolipoprotein involved in lipoprotein metabolism. It is a polymorphic protein and different isoforms are associated with variations in lipid and lipoprotein levels and thus cardiovascular risk. The isoform apoE4 is associated with an increase in LDL-cholesterol levels and thus a higher cardiovascular risk compared to apoE3. Whereas, apoE2 is associated with a mild decrease in LDL-cholesterol levels. In the presence of other risk factors, apoE2 homozygotes coul...
#1Ying-Ying ZhengH-Index: 8
#2Ting-Ting WuH-Index: 6
Last. Xiang XieH-Index: 1
view all 8 authors...
BACKGROUND AND AIMS The present study aimed to investigate the efficacy and safety of long-term (>18 months) dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI). METHODS A total of 3205 coronary artery disease (CAD) patients after PCI from CORFCHD-PCI, a retrospective cohort study (Identifier: ChiCTR-ORC-16010153), were divided into two groups: monotherapy of aspirin or clopidogrel group (SAPT group, n = 2188 and DAPT group, n = 1017) according to whether to discontin...
#1Norman E. Lepor (Cedars-Sinai Medical Center)H-Index: 20
#2Jie Sun (UW: University of Washington)H-Index: 19
Last. Xue-Qiao Zhao (UW: University of Washington)H-Index: 16
view all 12 authors...
Background and aims Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors reduce cardiovascular events, but their effects on atherosclerotic plaque remain elusive. Using serial magnetic resonance imaging (MRI), we studied changes in carotid plaque lipid content and neovasculature under PCSK9 inhibition with alirocumab. Methods Among patients with low-density lipoprotein cholesterol (LDL-C) ≥70 mg/dl but ineligible for high-dose statin therapy, those with lipid core on carotid MRI were...
#1Stephen T Vernon (Kolling Institute of Medical Research)H-Index: 4
#2Katharine A Kott (Kolling Institute of Medical Research)H-Index: 3
Last. Gemma A. FigtreeH-Index: 31
view all 14 authors...
Abstract Background and aims Targeting the modifiable risk factors for coronary artery disease (CAD) has substantial impact at the community level. However, it is not uncommon for individuals to present with atherosclerosis related events without identified risk factors. We examined sex differences in the association of risk factors and atherosclerotic burden assessed by CT coronary angiography (CTCA). Methods We analysed clinical and imaging data in 1002 individuals in the BioHEART cohort. Resu...
#1Amir Vahedian-Azimi (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 14
#2Somayeh Makvandi (IAU: Islamic Azad University)H-Index: 5
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 103
view all 5 authors...
ABSTRACT Background and aims Statins are the drugs of choice for decreasing elevated low-density lipoprotein cholesterol. Based mostly on animal studies and case reports, they are forbidden to pregnant women and in the preconception period because of their possible teratogenic effects, for which causality has never been proven. The aim of this study was to systematically review the existing studies and to perform a meta-analysis on this topic. Methods The databases PubMed/MEDLINE, Scopus, and We...
#1Aikaterini GatsiouH-Index: 10
#2Georgios Georgiopoulos (UoA: National and Kapodistrian University of Athens)H-Index: 24
Last. Konstantinos StellosH-Index: 52
view all 20 authors...
Abstract Background and aims Preclinical data suggest that the ageing-induced miR-34a regulates vascular senescence. Herein we sought to assess whether the miR-34 family members miR-34a, miR-34b and miR-34c are involved in human arterial disease. Methods Expression levels of miR-34a/b/c were quantified by TaqMan assay in peripheral blood mononuclear cells (PBMCs) derived from a consecutive cohort of 221 subjects who underwent cardiovascular risk assessment and thorough vascular examination for a...
#1Tejas P. Singh (JCU: James Cook University)H-Index: 9
#2Matthew A. Field (Australian Institute of Tropical Health and Medicine)H-Index: 24
Last. Jonathan Golledge (JCU: James Cook University)H-Index: 72
view all 5 authors...
Abstract Background and aims Abdominal aortic aneurysm (AAA) is an important cause of death worldwide and has an estimated heritability between 70 and 77%. Genome-wide association studies (GWAS) are an established way to discover genetic risk variants. The aim of this study was to systematically review the findings and quality of previous AAA GWAS. Methods The Medline, PubMed, Web of Science and relevant genetic databases were searched to identify previous AAA GWAS. A framework was developed to ...
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Diabetes mellitus