Biology

Botany

Aspergillus

Economics

Financial economics

Diterpene

Derivative (finance)

Chemistry

Fungus

Stereochemistry

Journal of Natural Products

Thirty-three metabolites including five phenalenone derivatives (1–5), seven cytochalasins (6–12), thirteen butenolides (13–25), and eight phenyl derivatives (26–33) were isolated from Aspergillus sp. CPCC 400735 cultured on rice. The structures of all compounds were elucidated by NMR, MS, and CD experiments, of which 1–5 (asperphenalenones A–E), 6 (aspochalasin R), and 13 (aspulvinone R) were identified as new compounds. Specifically, asperphenalenones A–E (1–5) represent an unusual structure composed of a linear diterpene derivative linked to a phenalenone derivative via a C–C bond. Compounds 1, 4, 10, and 26 exhibited anti-HIV activity with IC50 values of 4.5, 2.4, 9.2, and 6.6 μM, respectively (lamivudine 0.1 μM; efavirenz, 0.4 × 10–3 μM).

Metabolites from the Plant Endophytic Fungus <i>Aspergillus</i> sp. CPCC 400735 and Their Anti-HIV Activities

Metabolites from the Plant Endophytic Fungus Aspergillus sp. CPCC 400735 and Their Anti-HIV Activities