Original paper

Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages

Cell45.50
Volume: 171, Issue: 2, Pages: 331 - 345.e22
Published: Oct 1, 2017
Abstract
Clearance of apoptotic cells (ACs) by phagocytes (efferocytosis) prevents post-apoptotic necrosis and dampens inflammation. Defective efferocytosis drives important diseases, including atherosclerosis. For efficient efferocytosis, phagocytes must be able to internalize multiple ACs. We show here that uptake of multiple ACs by macrophages requires dynamin-related protein 1 (Drp1)-mediated mitochondrial fission, which is triggered by AC uptake....
Paper Details
Title
Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages
Published Date
Oct 1, 2017
Journal
Volume
171
Issue
2
Pages
331 - 345.e22
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