Understanding fetal factors that contribute to preterm birth: Sjögren-Larsson syndrome as a model

Aim: Preterm birth is the world’s leading cause of neonatal death. Unfortunately, the pathophysiology of preterm birth remains poorly understood. Sjögren-Larsson syndrome is a rare, neurometabolic disorder caused by a fatty aldehyde dehydrogenase deficiency. A majority of patients with Sjögren-Larsson syndrome is born preterm. Methods: Data of all known Dutch patients with Sjögren-Larsson syndrome and all cases reported in literature were...