Living systematic review: 1. Introduction-the why, what, when, and how.

Published on Sep 11, 2017in Journal of Clinical Epidemiology6.437
路 DOI :10.1016/J.JCLINEPI.2017.08.010
Julian Elliott60
Estimated H-index: 60
(Monash University),
Anneliese Synnot24
Estimated H-index: 24
(La Trobe University)
+ 10 AuthorsJames Thomas56
Estimated H-index: 56
(UCL: University College London)
Sources
Abstract
Systematic reviews are difficult to keep up to date, but failure to do so leads to a decay in review currency, accuracy, and utility. We are developing a novel approach to systematic review updating termed "Living systematic review" (LSR): systematic reviews that are continually updated, incorporating relevant new evidence as it becomes available. LSRs may be particularly important in fields where research evidence is emerging rapidly, current evidence is uncertain, and new research may change policy or practice decisions. We hypothesize that a continual approach to updating will achieve greater currency and validity, and increase the benefits to end users, with feasible resource requirements over time.
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Updating of systematic reviews is generally more efficient than starting all over again when new evidence emerges, but to date there has been no clear guidance on how to do this. This guidance helps authors of systematic reviews, commissioners, and editors decide when to update a systematic review, and then how to go about updating the review.
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Introduction Screening for prostate cancer remains controversial because of conflicting results from the two major trials: The Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) screening trial and the European Randomized Study of Screening for Prostate Cancer (ERSPC). Objective Meta-analyze and meta-regress the available PSA screening trials. Methods We performed a living systematic review and meta-regression of the reduction in prostate cancer mortality as a function of the duration of scree...
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Abstract Objectives To solicit experiences with and perceptions of rapid reviews from stakeholders, including researchers, policy makers, industry,聽journal editors, and health care providers. Study Design and Setting An international survey of rapid review producers and modified Delphi. Results Forty rapid review producers responded on our survey (63% response rate). Eighty-eight rapid reviews with 31 different names were reported. Rapid review commissioning organizations were predominantly gove...
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Julian Elliott and colleagues discuss how the current inability to keep systematic reviews up-to-date hampers the translation of knowledge into action. They propose living systematic reviews as a contribution to evidence synthesis to enhance the accuracy and utility of health evidence.
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Although meta-analyses are typically viewed as retrospective activities, they are increasingly being applied prospectively to provide up-to-date evidence on specific research questions. When meta-analyses are updated account should be taken of the possibility of false-positive findings due to repeated significance tests. We discuss the use of sequential methods for meta-analyses that incorporate random effects to allow for heterogeneity across studies. We propose a method that uses an approximat...
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Systematic reviews are difficult to keep up to date, but failure to do so leads to poor review currency and accuracy. "Living systematic review" (LSR) is an approach that aims to continually update a review, incorporating relevant new evidence as it becomes available. LSRs may be particularly important in fields where research evidence is emerging rapidly, current evidence is uncertain, and new research may change policy or practice decisions.This chapter describes the concept and processes of l...
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